Registration Dossier

Administrative data

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
13.12.1999 - 13.01.2000
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: The study was conducted by a well experienced research laboratory and in accordance with several internationally acknowledged guidelines.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2000

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
yes
Remarks:
The incubated solutions were filtered instead of centrifugated. The reequilibration temperature was 20 °C ± 2 °C instead of 20 °C ± 0.5 °C.
Qualifier:
according to
Guideline:
EPA OPPTS 830.7840 (Water Solubility)
Deviations:
yes
Remarks:
The incubated solutions were filtered instead of centrifugated. The reequilibration temperature was 20 °C ± 2 °C instead of 20 °C ± 0.5 °C.
Qualifier:
according to
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
yes
Remarks:
The incubated solutions were filtered instead of centrifugated. The reequilibration temperature was 20 °C ± 2 °C instead of 20 °C ± 0.5 °C.
GLP compliance:
not specified
Type of method:
flask method

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Water solubility
Water solubility:
2.15 g/L
Temp.:
20 °C
Remarks on result:
other: standard deviation: ± 0.04 g/L
Details on results:
Result of the Preliminary Test: The water solubility of 2,6-DMPA was estimated to be higher than 1 g/L by visual judgement

Any other information on results incl. tables

Results for Determination of the Water Solubility of 2,6-DMPA*

 Sample No.

 Shaking Time

at 30 °C

[h]

 Initial Weight

of 2,6-DMPA

[g]

 Initial Water

Volume

[mL]

 measured pH

after Incubation

Concentration

2,6-DMPA found

[mg/L]  

 1

72

1.0112

 20

 4.7

 2130

 2

 72

 1.0047

 20

 4.8

 2150

 3

 48

 1.002

 20

 4.7

 2110

 4

 48

 1.0047

 20

 4.3

 2130

 5

 24

 1.0119

 20

 4.4

 2170

 6

 24

 1.0658 20   4.3  2230

*The tabulated values represent rounded results, which were obtained by calculation using the exact raw data.

Quantification Limit was calculated tobe 480 mg test item/L (according to DIN 32645)

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): soluble (1000-10000 mg/L)
The water solubility of 2,6-DMPA was determined to be 2.15 g/L ± 0.04 g/L standard deviation at 20 °C ± 2 °C using the flask method for the
performance of the main test.