Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1999
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: The study was conducted by a well experienced research laboratory and in accordance with several internationally acknowledged guidelines.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1999
Report Date:
1999

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient)
Deviations:
yes
Remarks:
Acetonitril/water was used as mobile phase instead of methanole/ water as given in the guidelines
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
yes
Remarks:
Acetonitril/water was used as mobile phase instead of methanole/ water as given in the guidelines
Qualifier:
according to
Guideline:
EPA OPPTS 830.7570 (Partition Coefficient, n-octanol / H2O, Estimation by Liquid Chromatography)
Deviations:
yes
Remarks:
Acetonitril/water was used as mobile phase instead of methanole/ water as given in the guidelines
GLP compliance:
not specified
Type of method:
HPLC method
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent

Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficient
Type:
log Pow
Partition coefficient:
2.3
Temp.:
20 °C

Any other information on results incl. tables

Capacity Factor k' and log Pow of the Reference compounds

 Compound  Number of analysis  Retention Time [min]*  Capacity Factor1  log k'1  log Pow2
 Formamide ( = dead time)  3  1.83  n.a  n.a     n.a
 Reference Compounds:             
 Anilin  3  3.66  1.0  0.00     0.9
 4-Methoxyphenol  3  3.20  0.8  -0.12     1.3
Nitrobenzene  3  6.85  2.7  0.44     1.9
 Benzene  3  8.99  3.9  0.59     2.1
 Toluene  3  13.69  6.5  0.81     2.7
 Bromobenzene  3  15.69  7.6  0.88     3.0
 1,4-Dichlorobenzene  3  22.75  11.4  1.06    3.4  
 Biphenyl  3  30.66  15.8  1.20     4.0
 1,2,4-Trichlorobenzene  2  39.11  20.4  1.31     4.2
 Fluoranthene  3  70.29  37.4  1.57    4.7  

n.a. not applicable

1 values represent rounded results calculated from the exact raw data

2log Pow values as given in OECD Guideline No. 117

* mean value of three measurements

Capacity Factor k' and log Pow of the Test Substance

Compound   Number of analysis  Retention Time [min]*  Capacity Factor2  log k'   log Pow2
 2,6-DMPA  1  8.33 3.6  0.56  
 2,6-DMPA  2 8.33  3.6  0.56  
 2,6-DMPA  3  8.33  3.6  0.56  
 mean value1    8.33  3.6  0.56  2.3

1 mean value of three measurements, values represent rounded results calculated from the exact raw data

2 calculated according to equation I

3 calculated from regression data

Applicant's summary and conclusion

Conclusions:
The log Pow of 2,6-DMPA was determined to be 2.3 at 20°C.