Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 258-292-2 | CAS number: 53012-41-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1986
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
- Principles of method if other than guideline:
- see attached report
- GLP compliance:
- yes
Test material
- Reference substance name:
- 1-(2,6-dimethylphenoxy)acetone
- EC Number:
- 258-292-2
- EC Name:
- 1-(2,6-dimethylphenoxy)acetone
- Cas Number:
- 53012-41-2
- Molecular formula:
- C11H14O2
- IUPAC Name:
- 1-(2,6-dimethylphenoxy)propan-2-one
- Test material form:
- other: liquid undiluted
- Details on test material:
- - Name of test material (as cited in study report): 2,6-Dimethylphenoxyaceton
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Chbb:THOM
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Fa. Dr. K. Thomae, Biberach/Riß
- Age at study initiation: 56 - 57 days
- Weight at study initiation: male ca. 235.0 g ; female ca. 168.8 g
- Fasting period before study: 16 - 20 hours before application
- Housing: : Animals were housed individually in Makrolon cages type III
- Diet (e.g. ad libitum): ad libitum Altromin R 8013
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 6 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 - 26
- Humidity (%): 50 - 65
- Photoperiod (hrs dark / hrs light ) : 12 : 12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 1.6, 2.5 and 4.0 mL/kg corresponds to:
1648, 2575 and 4120 mg/kg - No. of animals per sex per dose:
- 5 animals per sex per dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations : clinical signs - permanent during Day 1 , than once or twice a day until Day 14
body weight - Day before application , Day 8 + 15
- Necropsy of survivors performed: yes - Statistics:
- Males:Probitanalyse
Females: logarithmic transformation of Dose-Values according Kärber-Procedure
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2 880 - 3 090 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Male, 2575 mg/kg , Number of animals : 5 ; Number of deaths : 3
Male, 4120 mg/kg , Number of animals : 5 ; Number of deaths : 3
Female, 2575 mg/kg , Number of animals : 5 ; Number of deaths : 2
Female, 4120 mg/kg , Number of animals : 5 ; Number of deaths : 5
12 animals died within 24 hours after application, 1 animal died on Day 2 after application - Clinical signs:
- other: face-down and lateral position, reduced motility, gasping, tachypnoe, vocalization, lacrimation, ataxia, salvia, coma, ( see full study report )
- Gross pathology:
- see full study report
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: not specified
- Conclusions:
- In conclusion, according to the Globally Harmonized Classification System, 2,6-Dimethylphenoxyaceton administered orally in male and female rats under the conditions of this study is considered that 2,6-Dimethylphenoxyaceton has not to be classified with an LD 50 of 2880 mg/kg bw.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.