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Administrative data

Workers - Hazard via inhalation route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
2 mg/m³
Most sensitive endpoint:
irritation (respiratory tract)
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Workers - Hazard via dermal route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified

Workers - Hazard for the eyes

Local effects

Hazard assessment conclusion:
high hazard (no threshold derived)

Additional information - workers

The DNELs for local inhalation effects are based on the corresponding DNELs that are available for hydrogen peroxide, taking into account that:

a) according to the stoichiometry of the hydrolysis reaction of calcium peroxide, an equimolar amount of hydrogen peroxide is formed; and that

b) the reaction mass of calcium carbonate and calcium dihydroxide and calcium peroxide typically contains 75% of calcium peroxide.

 

Worker – inhalation – local effects – long term

 

DNEL (hydrogen peroxide):          1.4 mg/m3

 

a) stoichiometrie

 

1.4 mg hydrogen peroxide             = 4.116E-05 mol hydrogen peroxide

                                                       = 4.116E-05 mol calcium peroxide

 

4.116E-05 mol calcium peroxide   = 3.0 mg calcium peroxide

 

DNEL (calcium peroxide)              = 3.0 mg/m3

 

b) composition of reaction mass

 

DNEL (calcium peroxide)              = 3.0 mg/m3

DNEL (reaction mass)                    = 4.0 mg/m3

 

As synergistic effects between hydrogen peroxide and calcium dihydroxide cannot be excluded (both have local effects), an extra assessment factor of 2 is taken into account.

 

The final DNEL for the reaction mass of calcium carbonate and calcium dihydroxide and calcium peroxide therefore is:

 

DNEL (reaction mass)                    = 2.0 mg/m3

 

General Population - Hazard via inhalation route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
0.3 mg/m³
Most sensitive endpoint:
irritation (respiratory tract)
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

General Population - Hazard via dermal route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified

General Population - Hazard via oral route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

General Population - Hazard for the eyes

Local effects

Hazard assessment conclusion:
high hazard (no threshold derived)

Additional information - General Population

The DNELs for local inhalation effects are based on the corresponding DNELs that are available for hydrogen peroxide, taking into account that:

a) according to the stoichiometry of the hydrolysis reaction of calcium peroxide, an equimolar amount of hydrogen peroxide is formed; and that

b) the reaction mass of calcium carbonate and calcium dihydroxide and calcium peroxide typically contains 75% of calcium peroxide.

 

 

General population – inhalation – local effects – long term

 

DNEL (hydrogen peroxide):          0.21 mg/m3

 

a) stoichiometrie

 

0.21 mg hydrogen peroxide            = 6.174E-06 mol hydrogen peroxide

                                                        = 6.174E-06 mol calcium peroxide

 

6.174E-06 mol calcium peroxide    = 0.44 mg calcium peroxide

 

DNEL (calcium peroxide)                = 0.44 mg/m3

 

b) composition of reaction mass

 

DNEL (calcium peroxide)                = 0.44 mg/m3

DNEL (reaction mass)                      = 0.59 mg/m3

 

As synergestic effects between hydrogen peroxide and calcium dihydroxide cannot be excluded, an extra assessment factor of 2 is taken into account.

 

The final DNEL for the reaction mass of calcium carbonate and calcium dihydroxide and calcium peroxide therefore is:

 

DNEL (reaction mass)                      = 0.3 mg/m3

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