Registration Dossier
Registration Dossier
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EC number: 908-343-6 | CAS number: -
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 2 mg/m³
- Most sensitive endpoint:
- irritation (respiratory tract)
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- high hazard (no threshold derived)
Additional information - workers
The DNELs for local inhalation effects are based on the corresponding DNELs that are available for hydrogen peroxide, taking into account that:
a) according to the stoichiometry of the hydrolysis reaction of calcium peroxide, an equimolar amount of hydrogen peroxide is formed; and that
b) the reaction mass of calcium carbonate and calcium dihydroxide and calcium peroxide typically contains 75% of calcium peroxide.
Worker – inhalation – local effects – long term
DNEL (hydrogen peroxide): 1.4 mg/m3
a) stoichiometrie
1.4 mg hydrogen peroxide = 4.116E-05 mol hydrogen peroxide
= 4.116E-05 mol calcium peroxide
4.116E-05 mol calcium peroxide = 3.0 mg calcium peroxide
DNEL (calcium peroxide) = 3.0 mg/m3
b) composition of reaction mass
DNEL (calcium peroxide) = 3.0 mg/m3
DNEL (reaction mass) = 4.0 mg/m3
As synergistic effects between hydrogen peroxide and calcium dihydroxide cannot be excluded (both have local effects), an extra assessment factor of 2 is taken into account.
The final DNEL for the reaction mass of calcium carbonate and calcium dihydroxide and calcium peroxide therefore is:
DNEL (reaction mass) = 2.0 mg/m3
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.3 mg/m³
- Most sensitive endpoint:
- irritation (respiratory tract)
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- high hazard (no threshold derived)
Additional information - General Population
The DNELs for local inhalation effects are based on the corresponding DNELs that are available for hydrogen peroxide, taking into account that:
a) according to the stoichiometry of the hydrolysis reaction of calcium peroxide, an equimolar amount of hydrogen peroxide is formed; and that
b) the reaction mass of calcium carbonate and calcium dihydroxide and calcium peroxide typically contains 75% of calcium peroxide.
General population – inhalation – local effects – long term
DNEL (hydrogen peroxide): 0.21 mg/m3
a) stoichiometrie
0.21 mg hydrogen peroxide = 6.174E-06 mol hydrogen peroxide
= 6.174E-06 mol calcium peroxide
6.174E-06 mol calcium peroxide = 0.44 mg calcium peroxide
DNEL (calcium peroxide) = 0.44 mg/m3
b) composition of reaction mass
DNEL (calcium peroxide) = 0.44 mg/m3
DNEL (reaction mass) = 0.59 mg/m3
As synergestic effects between hydrogen peroxide and calcium dihydroxide cannot be excluded, an extra assessment factor of 2 is taken into account.
The final DNEL for the reaction mass of calcium carbonate and calcium dihydroxide and calcium peroxide therefore is:
DNEL (reaction mass) = 0.3 mg/m3
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