Registration Dossier
Registration Dossier
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EC number: 231-104-6 | CAS number: 7439-95-4
Endpoint summary
Administrative data
Description of key information
Magnesium is a cofactor of many enzymes involved in intermediary metabolism. Magnesium is absorbed in the intestinal tract and excreted into the digestive tract by bile and pancreatic and intestinal juices. There is an apparent obligatory urinary loss of magnesium, which amounts to about 12 mg/day and the urine is the major route of excretion under normal conditions. Unabsorbed magnesium is excreted in the feces.. Magnesium is filtered by the glomeruli and reabsorbed by renal tubules. In the blood plasma, about 65 percent is the ionic form while the remainder is bound to protein. Excretion also occurs via the sweat and milk. Approximately 70 percent of serum magnesium is ultrafilterable, and about 95 percent of the filtered magnesium is reabsorbed, which is an important factor in maintaining magnesium homeostasis. Tissue distribution studies indicate that of 20 g body burden in humans, the majority is intracellular in the bone and muscle including the myocardium, but some magnesium is present in every cell of the body.
Additional information
Magnesium is a cofactor of many enzymes involved in intermediary metabolism. Magnesium is absorbed in the intestinal tract and excreted into the digestive tract by bile and pancreatic and intestinal juices. There is an apparent obligatory urinary loss of magnesium, which amounts to about 12 mg/day and the urine is the major route of excretion under normal conditions. Unabsorbed magnesium is excreted in the feces.. Magnesium is filtered by the glomeruli and reabsorbed by renal tubules. In the blood plasma, about 65 percent is the ionic form while the remainder is bound to protein. Excretion also occurs via the sweat and milk. Approximately 70 percent of serum magnesium is ultrafilterable, and about 95 percent of the filtered magnesium is reabsorbed, which is an important factor in maintaining magnesium homeostasis. Tissue distribution studies indicate that of 20 g body burden in humans, the majority is intracellular in the bone and muscle including the myocardium, but some magnesium is present in every cell of the body.
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