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EC number: 229-419-9
CAS number: 6528-34-3
Worker DNELs have not been derived for pigments of the Mono Azo Yellow
group because the substances of this category did not cause relevant
toxictiy in any test performed according to the information requirements.
- the substances of this category did not cause lethal effects after
administration of a single oral dose of >= 2000 mg/kg or a single dermal
dose of 2000 mg/kg in rats,
- the substances of this category are not irritating and do not have to
be classified as eye or skin irritants,
- the substances of this category caused no relevant systemic toxic
effects in several subacute oral studies in rats (NOAEL 1000 mg/kg/day),
and in a subchronic oral toxicity study in rats (NOAEL 1000 mg/kg/day),
- the substances of this category caused no systemic toxic effects, no
effects on fertility or development in a Combined Repeated Dose Toxicity
Study with the Reproduction / Developmental Toxicity Screening Test
(OECD Guideline 422; NOAEL 1000 mg/kg bw/day),
- the absence of effects in the above-mentioned toxicity endpoint tests
indicates that the substances of this category do not interact with
living cells/tissues, and
- it is unlikely that the substances of this category become
systemically bioavailable due to their extremely low solubility in water
and low solubility in n-octanol. The substances of this category are not
likely to be systemically available after oral, dermal or inhalation
Therefore no DNELs for systemic effects have been derived.
Mono Azo Yellow Pigments do not cause irritation, corrosion or
sensitization. They are considered unlikely to become bioavailable in
the skin and are considered not to be classified regarding respiratory
tract irritation. No substance specific effects are expected for the
pigments of this category after local exposure, therefore no DNELs for
local effects have been derived.
Apart from that, relevant occupational exposure limits for inert dusts
should be applied.
DNELs for the general population have not been derived for pigments of
the Mono Azo Yellow group because the substances of this category did
not cause relevant toxictiy in any test performed according to the
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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