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EC number: 234-682-8 | CAS number: 12023-53-9
Summary of offspring clinical observations
Group (Dose mg/kg/day)
Number of offspring (litters) affected
Head: bruising and swelling
Umbilical cord attached
Dorsal surface: Scab and reddening
A combined repeat dose toxicity study and reproductive / developmental toxicity screening study in rats was conducted (Huntingdon Life Sciences, 2012) to assess the effect of Fe3P on rats following repeated oral administration. The study was conducted according to OECD test guideline 422, and in compliance with GLP.
Male and female rats were administered Fe3P by oral gavage for five weeks (males, and toxicity phase females), or for two weeks before mating, during mating and gestation, and until day six of lactation (main phase females). The dose groups were 100, 300, and 1000 mg/kg/day, and a concurrent control group was administered with untreated vehicle.
Reproductive performance was not affected by treatment with test material; the assessed factors included mating performance, fertility and offspring survival. No adverse effects were seen on offspring development up to Day 7 of age.
On the basis of this study, the No Observed Adverse Effect Level for reproductive and developmental toxicity is considered to be 1000 mg/kg/day.
NOAEL, rat, oral exposure = 1000 mg/kg/day
Refer to fertility discussion for details.
In the above reproductive / developmental toxicity screening study, no effects were observed on the reproduction of rats following repeated exposure to Fe3P, and no adverse effects were seen on the development of offspring. There is therefore no basis on which to justify calssification of Fe3P for reproductive or developmental toxicity.
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