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EC number: 234-682-8 | CAS number: 12023-53-9
There were no deaths and no signs of ill health or toxicity observed during this study, however the following observations were noted:
Greasy fur was noted for all control and test animals post-dose from Day 1 for control animals and from Day 3 for all test animals. This sign had resolved completely in all animals by Day 5.
Black dose residue on ears was noted for all test animals post-dose on Day 1. Wet fur was also noted for all test animals post-dose on Day 1. These signs had resolved completely in all animals by Day 4.
A Local Lymph Node Assay (Huntingdon Life Sciences, 2010) was conducted to assess the potential for Fe3P to cause skin sensitization. The study was conducted according to OECD test guideline 429 and EC guideline B42, and in compliance with GLP.
Test groups of four mice per concentration were administered daily applications of 25 µL of vehicle (acetone : olive oil, 4:1 (v/v)), 25%, 50%, or100% w/v Fe3P in vehicle to the dorsal surface of both ears for three consecutive days. The proliferative response of the lymph node cells was then assessed five days after the initial application. Test control ratios (ratio of the proliferative response seen in test groups relative to the control group) were 0.7, 0.5, and 0.8 for the 25%, 50%, and 100% groups, respectively, and on this basis Fe3P is not considered to be a potential sensitizer.
The Local Lymph Node Assay (LLNA, Huntingdon Life Sciences, 2010) conducted on Fe3P concluded that it was not a potential sensitizer. On this basis, it may be stated conclusively that Fe3P should not be classified as a dermal sensitizer under either the CLP Regulation (1272/2008) or the Dangerous Substances Directive (67/548/EEC).
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