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EC number: 701-438-1 | CAS number: -
Particle size distribution (Granulometry)
Administrative data
Link to relevant study record(s)
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2010-08-03 to 2010-11-19
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- signed 2010-03-22
- Type of method:
- microscopic examination
- Type of particle tested:
- primary particle
- Type of distribution:
- mass based distribution
- Specific details on test material used for the study:
- Appearance: solid
Storage conditions: room temperature - Remarks on result:
- not measured/tested
- No.:
- #1
- Size:
- >= 105 - <= 130 µm
- Distribution:
- 0 %
- Remarks on result:
- other: Mean of six replicates
- No.:
- #2
- Size:
- >= 60 - <= 105 µm
- Distribution:
- 0 %
- Remarks on result:
- other: Mean of six replicates
- No.:
- #3
- Size:
- >= 30 - <= 60 µm
- Distribution:
- 0 %
- Remarks on result:
- other: Mean of six replicates
- No.:
- #4
- Size:
- >= 10.4 - <= 30 µm
- Distribution:
- 69.4 %
- Remarks on result:
- other: Mean of six replicates
- No.:
- #5
- Size:
- >= 0.5 - <= 10.4 µm
- Distribution:
- 30.6 %
- Remarks on result:
- other: Mean of six replicates
Reference
Results
The reported results were prepared from at least fifty fields from each slide. The mean
projected area data were used to calculate spherical particle volumes in each range, which,
when combined with the particle number distribution, gives a volume or mass distribution.
The observed particles were predominantly dark and irregularly shaped.
Description of key information
The observed particles were predominantly dark and irregularly shaped. All particles were smaller than 30 µm, with ca. 70% (w/w) in the range 10.4-30 µm, and 30%(w/w) in the range 0.5-10.4 µm.
Additional information
A particle size distribution determination was performed as part of a set of tests for physico-chemical properties (Huntingdon Life Sciences, 2011, Study FGE0002). The particle size distribution was determined according to OECD Method 110, and the study was conducted in compliance with GLP. An initial sieve analysis was followed by an automated microscopic image analysis.
The observed particles were predominantly dark and irregularly shaped. All particles were smaller than 30 µm, with ca. 70% (w/w) in the range 10.4-30 µm, and 30%(w/w) in the range 0.5-10.4 µm.
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