Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 201-936-4 | CAS number: 89-75-8
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- significant methodological deficiencies
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 972
- Report date:
- 1972
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- GLP compliance:
- not specified
Test animals
- Species:
- rabbit
Administration / exposure
- Doses:
- 316 mg/kg, 1000 mg/kg, 3160 mg/kg, 10000 mg/kg
- No. of animals per sex per dose:
- 2 per dose
- Details on study design:
- range finding study
Results and discussion
Effect levels
- Dose descriptor:
- LD50
- Effect level:
- 3 160 mg/kg bw
- Clinical signs:
- other: depression, ataxia, labored respiration
- Gross pathology:
- None except dark red spots on kidney surface in one rabbit which survived 3160 mg/kg
Applicant's summary and conclusion
- Conclusions:
- LD50 in rabbits is 3160 mg/ kg
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