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Diss Factsheets
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EC number: 201-936-4 | CAS number: 89-75-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- significant methodological deficiencies
- Remarks:
- The determination of dose is unclear, dead animals were removed from evaluation Redness and edema have been reported but assessment is nevertheless not sensitizing.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 972
- Report date:
- 1972
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
- Type of study:
- other: modified Landsteiner
Test material
- Reference substance name:
- 2,4-dichlorobenzoyl chloride
- EC Number:
- 201-936-4
- EC Name:
- 2,4-dichlorobenzoyl chloride
- Cas Number:
- 89-75-8
- Molecular formula:
- C7H3Cl3O
- IUPAC Name:
- 2,4-dichlorobenzoyl chloride
- Reference substance name:
- Benzoylchloride, 2,4-dichloro-
- IUPAC Name:
- Benzoylchloride, 2,4-dichloro-
- Test material form:
- solid: crystalline
- Details on test material:
- light yellow, unpleasant ordor,cristalline powder
Constituent 1
Constituent 2
In vivo test system
Test animals
- Species:
- guinea pig
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Vehicle:
- other: Sesame oil 0.1 %
- Concentration / amount:
- Sensitizing injections:
0.1 % solution in sesame oil
First dose 0.05 mL, succeding dose 0.1 mL per animal
Challengeopen allclose all
- Vehicle:
- other: Sesame oil 0.1 %
- Concentration / amount:
- Sensitizing injections:
0.1 % solution in sesame oil
First dose 0.05 mL, succeding dose 0.1 mL per animal
- No. of animals per dose:
- test concentrations: 8
vehicle control and positive control: 4 - Details on study design:
- MAIN STUDY
A. INDUCTION EXPOSURE
- No. of exposures: three times per week
- Exposure period: three weeks
- Site: into the clipped back and flanks
B. CHALLENGE EXPOSURE
- No. of exposures: one time
- Day(s) of challenge: 10 days after last sensitizing dose. - Challenge controls:
- Following the last sensitising dose, the animals were set aside for 10 days after a challenge dose (0.05 ml of freshly prepared solution) was administered.
There were no responses to the challenge dose. - Positive control substance(s):
- yes
- Remarks:
- DNCB
Results and discussion
In vivo (non-LLNA)
Results
- Reading:
- other: After challenge
- Hours after challenge:
- 48
- Group:
- test chemical
- No. with + reactions:
- 8
- Total no. in group:
- 8
- Clinical observations:
- no clinical observations
- Remarks on result:
- other: Reading: other: After challenge. . Hours after challenge: 48.0. Group: test group. No with. + reactions: 8.0. Total no. in groups: 8.0. Clinical observations: no clinical observations.
Any other information on results incl. tables
One animal showed slight swelling without erythema following one of the sensitizing doses which might be due to mechanical factores and do not represent true sensitizing response.
Applicant's summary and conclusion
- Conclusions:
- In conclusion it can be said that the test item is not sensitising to Guinea Pigs under the conditions of the test.
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