Registration Dossier
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EC number: 940-730-5 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
All reliable in vivo studies on skin and eye irritation for "hydrocarbons, C14-C20, aliphatics, <=2% aromatics" show no or slight irritation effects on rabbit skin and eyes. These results are read across to Hydrocarbons, C15-C19, n-alkanes, isoalkanes, <2% aromatics and are confirmed by in vitro studies on the substance itself.
In all studies on human volunteers with related substances, there were no signs of irritation or sensitisation effects of the test substances.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Animal studies:
Hydrocarbons, C15-C19, n-alkanes, isoalkanes, <2% aromatics has been tested in an in vitro assay conducted according to OECD TG 439 and in compliance with GLP (Westerink, 2014a). The test substance was applied to a human three dimensional epidermal model, EPISKIN-SMTM, for 15 minutes. The positive control had mean relative skin viability (the measure of irritancy) of 21%, and an optical density at 570 nm very slightly below the historical control data range. The mean relative skin viability of the test substance was 91%, so it was concluded that the test substance is not irritant under the conditions of this test.
Fourteen reliable studies were available for skin irritation, dealing with the toxicity of different samples of “Hydrocarbons, C14-C20, aliphatics, =2% aromatics”. All studies were conducted similarly or according to OECD guideline 404. All studies show no or slight irritation effects on rabbits' skin. One reliable study was performed with human volunteers exposed to isohexadecane and isoeicosane for 24 h in occlusive conditions. Only slight signs of irritation lead to the conclusion that test substances were not skin irritant.
Hydrocarbons, C15-C19, n-alkanes, isoalkanes, <2% aromatics has been tested in a bovine corneal opacity in vitro assay (BCOP test) conducted according to OECD TG 437 and in compliance with GLP (Westerink, 2014b). The endpoints assessed in this assay are opacity and permeability; negative and positive controls gave expected results. The test substance did not induce ocular irritation as assessed by both endpoints.
Nine studies were available for eye irritation, dealing with the toxicity of different samples of “Hydrocarbons, C14-C20, aliphatics, =2% aromatics”. All studies were conducted similarly or according to OECD guideline 405. All studies show no or slight irritation effects on rabbits' eyes. These results are read-across to hydrocarbons, C15-C19, n-alkanes, isoalkanes, <2% aromatics.
Human information
Seven studies were available on the irritation and/or sensitisation potential of several types of hydrocarbon solvents in volunteers. Clinical tests were conducted with populations ranging from 29 to 112 patients. None of the test substances elicited any sensitisation and/or irritation effects except C5-C20 paraffin, which showed a cumulative irritation effect at 75% (Barsotti, 1995). However, this substance was tested under occlusive patch, a condition which exacerbates the irritancy of hydrocarbon solvents.
Justification for classification or non-classification
As all reliable studies show no irritation effect or irritation effects slight enough not to classify the test materials, Hydrocarbons, C15-C19, n-alkanes, isoalkanes, <2% aromatics does not need to be classified as irritant for skin and eye according to the criteria of Annex VI of Directive 67/548/EEC and Regulation (EC) No 1272/2008.
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