Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 941-224-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- 2004
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Vehicle:
- no
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna STRAUS
- Strain/clone: RWTH Aachen University, Institute for Environmental Research (Biology V)
Worringerweg 1
52074 Aachen
Germany
- Age at study initiation (mean and range, SD): < 24 h
- Method of breeding: M4 medium (according to OECD 202) until 48 hours before test start, thereafter, maintained in 100 % test medium (AAP test medium according to OECD 201) at the test temperature for at least 48 hours prior test start
- Source: held and bred in the test facility under standardised laboratory conditions, test animals derived from a healthy stock, not first brood progeny
- Feeding during test : no
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- 140 - 250 mg/L (CaCO3)
- Test temperature:
- 20.3 – 20.5 °C (recorded continuously)
- pH:
- 6.69 -7.52
- Dissolved oxygen:
- 7.51 - 8.82 mg/L
- Nominal and measured concentrations:
- Control (0), 197.6, 296.4, 444.6, 666.9, 999.7 mg/L test item;
Control (0), 196.8, 295.1, 442.7, 664.0, 995.4 mg/L active substance
Recoveries for fresh samples were in the range from 106 to 109% of nominal, recoveries for spent samples were in the range from 111 to 115%. No test item was found in the control samples. - Details on test conditions:
- TEST SYSTEM
- Test vessel: glass beaker (25 mL)
- Type (delete if not applicable): open
- Material, size, headspace, fill volume: 10 mL
- Volume of solution: 10 mL
- Aeration: no
- No. of organisms per vessel: 20
- No. of vessels per concentration (replicates): 4 + 3 additional vessels (1 for measuring of water parameters, 1 for analysis, 1 retain specimen)
- No. of vessels per control (replicates): 4 + 3 additional vessels (1 for measuring of water parameters, 1 for analysis, 1 retain specimen)
- Biomass loading rate: 2 mL test solution per Daphnia
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: AAP medium according to OECD 201
- Culture medium different from test medium: same for last 48 hour prior to obtaining the neonates for this test
- Intervals of water quality measurement: 0 and 48 hours
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16/8 light/dark phases
- Light intensity: on average 20 µE *m-2*s-1
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
EC50 48 hours
VEHICLE CONTROL PERFORMED: no
- Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 602 mg/L
- 95% CI:
- >= 534.6 - <= 679.3
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- other: immobilization
- Details on results:
- - Behavioural abnormalities: No abnormal behaviour or appearance was observed (e.g. trapping at surface of water or discoloration) in the control treatment and at the test concentrations ≤ 444.6 mg/L test item. At the test concentrations of 666.9 and 999.7 mg/L test item some daphnids trapped at surface of the test solution and showed active swimming after pressing the daphnids below the water surface.
- Mortality of control: none
- Other adverse effects control: none
- Immobilisation of control: none
- Abnormal responses: none
- Any observations (e.g. precipitation) that might cause a difference between measured and nominal values: no ne
- Effect concentrations exceeding solubility of substance in test medium: no - Results with reference substance (positive control):
- - Results with reference substance valid?
yes
- Dose-response test: yes
- EC50: 1.76 - Reported statistics and error estimates:
- The EC10, EC20 and EC50 values were calculated by Probit analysis according to the maximum likelihood method. During the probit analysis the logarithm of the test concentrations was used to present the ECx results in the figure.
Statistical analysis was performed using the software ToxRat Professional (Version 3.3, Ratte, 20.10.2018) - Validity criteria fulfilled:
- yes
- Conclusions:
- 48h-EC50: 602 mg a.s./L
- Executive summary:
The acute toxicity of Reaction mass of sodium (methylbutyl and pentyl) sulfonate and sodium 1,2-bis(pentyloxycarbonyl)ethanesulphonate to Daphnia magna was determined in a static GLP compliant test. The test was performed according to guideline OECD 202. The test was started with a control and nominal 197.6, 296.4, 444.6, 666.9, 999.7 mg/L test item corresponding to 0 (control), 196.8, 295.1, 442.7, 664.0, 995.4 mg/L active substance. For each test concentration and the control, 4 replicates with 5 daphinds each were set up in 10 mL vessels. Recoveries for fresh samples were in the range from 106 to 109% of nominal, recoveries for spent samples were in the range from 111 to 115%. Consequently, the test concentration was stable and the reported biological results are related to the nominal test item concentration.No test item was found in the control samples. The 48 h EC50 value is 602 mg active substance/L (95% C.I. 534.6 to 679.3 mg active substance /L).
The results of this study are considered to be reliable and relevant for the risk assessment of the substance registered with this dossier.
Reference
Description of key information
EC50 freshwater invertebrates: > 602 mg a.s. /L
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- EC50
- Effect concentration:
- 602 mg/L
Additional information
The acute toxicity of Reaction mass of sodium (methylbutyl and pentyl) sulfonate and sodium 1,2-bis(pentyloxycarbonyl)ethanesulphonate to Daphnia magna was determined in a static GLP compliant test. The test was performed according to guideline OECD 202. The test was started with a control and nominal 197.6, 296.4, 444.6, 666.9, 999.7 mg/L test item corresponding to 0 (control), 196.8, 295.1, 442.7, 664.0, 995.4 mg/L active substance. For each test concentration and the control, 4 replicates with 5 daphinds each were set up in 10 mL vessels. Recoveries for fresh samples were in the range from 106 to 109% of nominal, recoveries for spent samples were in the range from 111 to 115%. Consequently, the test concentration was stable and the reported biological results are related to the nominal test item concentration. No test item was found in the control samples. The 48 h EC50 value is 602 mg active substance/L (95% C.I. 534.6 to 679.3 mg active substance /L).
The results of this study are considered to be reliable and relevant for the risk assessment of the substance registered with this dossier.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.