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Dissociation constant

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Description of key information

pKa < 3;  When using citric acid, no inflection point was obtained therefore the Dissociation Constants in Water of the test item cannot be determined by the Titration Method. During the A.6 Water Solubility analysis, UV spectra revealed no absorption maxima therefore the UV method is also not suitable.

Key value for chemical safety assessment

Additional information

In the GLP Klimisch 1 study from Younis (2014) the dissociation constant of the registered substance was determined according to test method OECD 112. When using citric acid, no inflection point was obtained therefore the Dissociation Constants in Water of the test item cannot be determined by the Titration Method. The pKa is < 3. During the A.6 Water Solubility analysis, UV spectra revealed no absorption maxima therefore the UV method is also not suitable.

This value will be used for the risk assessment.