Registration Dossier
Registration Dossier
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EC number: 206-007-7 | CAS number: 286-20-4
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- Not reported.
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: A non-GLP study conducted to scientific principles with a sufficient level of detail to assess the quality of the presented results.
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- The Pharmacology of Certain Terpene Alcohols & Oxides
- Author:
- Northover B J & Verghese J
- Year:
- 1 962
- Bibliographic source:
- Journal of Scientific & Industrial Research, Vol. 21C,No. 12, 342-345
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Groups of 10 mice received intramuscular injections of test material at graded doses. Mortality was observed during the 48 hours following treatment to allow determination of an LD50 value.
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- 1,2-epoxycyclohexane
- EC Number:
- 206-007-7
- EC Name:
- 1,2-epoxycyclohexane
- Cas Number:
- 286-20-4
- Molecular formula:
- C6H10O
- IUPAC Name:
- 7-oxabicyclo[4.1.0]heptane
- Test material form:
- not specified
- Details on test material:
- - Name of test material (as cited in study report): cyclohexene oxide
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- intramuscular
- Vehicle:
- not specified
- Doses:
- 4, 6, 8, 10 and 12 g/kg
- No. of animals per sex per dose:
- 10 animals per dose
- Control animals:
- not specified
- Details on study design:
- Animals were exposed via intramuscular injections in groups of 10 to graded doses of the test material.
The animals were observed for 48 hours following treatment with the test material and deaths were recorded. - Statistics:
- The number of animals which died was plotted against the dose administered to calculate the LD50.
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 1 other: g/kg
- Based on:
- test mat.
Any other information on results incl. tables
No further information on results is presented.
Applicant's summary and conclusion
- Conclusions:
- The acute toxicity of the test material was determined by administering test material to mice by intramuscular injection. Under the conditions of the study, the LD50 of the test material was determined to be 1000 mg/kg body weight.
- Executive summary:
Groups of 10 mice received intramuscular injections of test material at graded doses. Mortality was observed during the 48 hours following treatment to allow determination of an LD50 value. Under the conditions of the study, the LD50 of the test material was determined to be 1000 mg/kg body weight.
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