Registration Dossier
Registration Dossier
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EC number: 206-007-7 | CAS number: 286-20-4
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- Not reported
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: The study report is presented in an abstract; very little information is available regarding the method of exposure. It is therefore not possible to assess the accuracy of the data.
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Irritation and corrosivity observations were performed as part of an aucte dermal toxiicty study. The test material was held in prolonged contact with the skin of a rabbit and the resultant skin reaction was noted.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1,2-epoxycyclohexane
- EC Number:
- 206-007-7
- EC Name:
- 1,2-epoxycyclohexane
- Cas Number:
- 286-20-4
- Molecular formula:
- C6H10O
- IUPAC Name:
- 7-oxabicyclo[4.1.0]heptane
- Test material form:
- not specified
- Details on test material:
- - Name of test material (as cited in study report): cyclohexene oxide
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- not specified
- Controls:
- not specified
- Duration of treatment / exposure:
- The test animal was exposed for 24 hrs.
Results and discussion
In vivo
Results
- Remarks on result:
- other: Under the conditions of the study, the test material was shown to cause a severe reaction to the skin, leaving chemical like burns.
- Irritant / corrosive response data:
- Exposure to the test material resulted in moderate to severe chemical burns.
- Other effects:
- The LD50 of the test material was greater than 1000 mg/kg bw.
Applicant's summary and conclusion
- Interpretation of results:
- highly corrosive
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- Under the conditions of the study, the test material was shown to cause a severe reaction to the skin, leaving chemical like burns.
- Executive summary:
The irritation potential of the test material to the skin was determined in an unspecified species of rabbit. The study records that moderate to severe chemical burns were caused as a result of dermal exposure over a 24 hour period. There is no available information regarding the methods used, so it is not possible to assess the accuracy of the data from the available information.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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