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EC number: 250-437-8 | CAS number: 31024-56-3
Oral (similar to OECD TG 401), rat: LD50 = 12 828 mg/kg bw (male)Dermal (similar to OECD TG 402), rabbit: LD50 = 15 200 mg/kg bw (male)Inhalation: no reliable data available
Acute toxicity: oral
In the available key study (Bushy Run Research Center, 1981) the test item was tested according to a test protocol that is similar to the OECD TG 401, but without compliance with GLP. 5 male Wistar rats each group received the undiluted test material at doses of 475, 950, 1900, 3800, 7600, and 15 200 mg/kg bw via gavage. No deaths occurred and no signs of toxicity were observed at the low dose of 475 mg/kg bw. At higher doses, deaths occured and salivation, unsteady gait, diarrhoea, and sluggishness were observed. At the high dose, 3/5 animals died 30-35 min after dosing. Macroscopic evaluation revealed that in victims, the stomach was gas-filled, the glandular portions were injected, and the intestines were injected or contained blood. In survivors, nothing remarkable was observed. The LD50 was determined to be 12 825 mg/kg bw.
Acute toxicity: dermal
In the available key study (Bushy Run Research Center, 1981) the test item was tested for acute dermal toxicity according to a test protocol that is comparable to the OECD test guideline 402, but without GLP compliance. The test material was occlusively administered to 4 male New Zeeland White rabbits each dose group for 24 h. The LD50 was determined to be 15 200 mg/kg bw. The predominant clinical signs detected were signs of irritation/corrosion, such as erythema, oedema, and necrosis. No deaths occurred at 1900 mg/kg bw, but still signs of skin irritation were noted.
Acute toxicity: inhalation
No reliable data is available for acute toxicity via inhalation. In accordance with Column 2 of REACH Annex VIII, the acute toxicity study via the inhalation route (required in Section 8.5.2 of REACH Annex VIII) does not need to be conducted as reliable data via the oral and dermal routes are available. Nevertheless, supporting data derived from a summary report is available (Bushy Run Research Center, 1981). In this non-guideline study, which was not compliant to GLP, the test item was tested for acute inhalation toxicity. Substantially saturated vapour did not cause any deaths or signs of toxicity in any of the male rats after 6 h of exposure. The LC50 was found to be >vapour saturation at 25°C.
The available data is reliable and suitable for classification. Based on this data, classification for acute toxicity according to EC/1272/2008 is not warranted.
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