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EC number: 250-437-8 | CAS number: 31024-56-3
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
Toxicity to microorganisms: EC50 > 1000 mg/l
Key value for chemical safety assessment
Additional information
There are no microorganism toxicity data available for N-[3-(trimethoxysilyl)propyl]butylamine (CAS No. 31024-56-3), therefore good quality data for the analogue substance, N-[3-(trimethoxysilyl)propylcyclohexylamine] (CAS No. 3068-78-8) have been read across. Both substances share comparable silanol hydrolysis products, N-[3-(trihydroxysilyl)propyl]butylamine N-[3-(trihydroxysilyl)propylcyclohexylamine]. It is therefore considered valid to read-across the results for N-[3-(trimethoxysilyl)propylcyclohexylamine] to fill the data gap for the registered substance. The other hydrolysis product is methanol, which does not have adverse effects on microorganisms (OECD, 2004).
Both substances are within a wider analogue group than the analogue group discussed in Section 1.4. Substances within this wider analogue group, in general, exhibit no evidence of significant toxicity to microorganisms.
This wider analogue group for the toxicity to microorganisms endpoint consists of a number of sub-classes of substances. However, read-across is carried out between substances with the same sub-class in most cases.
Table7.1.6 presents microorganism toxicity data available for substances within the sub-class (III-8) of substances having amino group(s) in side chain after any very rapid hydrolysis has been accounted for. Both N-[3-(trimethoxysilyl)propyl]butylamine (CAS No. 031024-56-3) and N-[3-(trimethoxysilyl)propylcyclohexylamine] (CAS No. 3068-78-8) are members of this sub-class.
Table 7.1.6. Microorganism toxicity data available for substances within the relevant sub-class (III-8) of chemicals
CAS | Name | Result: E(I)C50(mg/l) | Result: NOEC (or EC10/ EC20) (mg/l) | Guideline Number | Test method | Species | Duration | Reliability |
027445-54-1 | Cyclohexanamine,N-[(diethoxymethylsilyl)methyl]- | 624.2 mg/l (EC20 240.2 mg/l) |
| OECD 209 | ASRI |
| 3hr - but stirred 24hr | 1a |
003068-78-8 | N-[3-(trimethoxysilyl)propylcyclohexylamine] | >1000 | EC20 = 203 mg/l | OECD 209 | ASRI |
| 3 hr | 1a |
157923-74-5 | 2,2-dimethyl-4-(trimethoxysilyl)butylamine | >1000 | EC15 869. 17.5% inhibition at 1000 mg/l. | OECD 209 | ASRI |
| 3 hr | 1a |
227085-51-0 | N-ethyl-3-trimethoxysilyl-2-methylpropanamine | >1000 |
| OECD 209 | ASRI |
| 3 hr | 1a |
000919-30-2 | 3-aminopropyltriethoxysilane | 43 mg/l | EC10 13 mg/l | Huls AG method | oxygen consumption | P. putida | 5.75 hr | 2c |
082985-35-1 | Bis(trimethoxysilylpropyl)amine | estimated value, approximately 1000 | 220 | OECD 209 | ASRI |
| 3 hr | 1a |
001760-24-3 | N-(3-(trimethoxysilyl)propyl)ethylenediamine | 67 mg/l | EC10 25 mg/l | DIN 38 412, Part 8 (Pseudomonascell multiplication inhibition test) | growth inhibition test | P. putida | 16 hr | 1c |
[N,N-Bis(trimethylsilyl)aminopropyl]methyldiethoxysilane | >100 |
| OECD 209 | ASRI |
| 3 hr | 1a | |
None | reaction mix (reaction mass of 6 benzylated amine silanes) | 569 | 130; EC20 172 | OECD 209; EC C.11 | ASRI |
| 3 hr | 1a |
Additional information is given in a supporting report (PFA, 2013l) attached in Section 13 of the IUCLID 5 dossier
The influence of the test item N-[3-(trimethoxysilyl)propylcyclohexylamine] (CAS No. 3068-78-8) were determined in a reliable study conducted according to OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test) and GLP (Ibacon, 1998). An EC50of > 1000 mg/l was determinated.
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