N-[3-(trimethoxysilyl)propyl]butylamine

Short-term toxicity to aquatic invertebrates

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Justification for type of information:

Please refer to the analogue approach justification provided in section 13.

Reason / purpose:

read-across source

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

> 100 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mobility

Duration:

48 h

Dose descriptor:

NOEC

Effect conc.:

100 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mobility

Conclusions:

A 48-h EC50 >100 mg/l in Daphnia magna was determined in a guideline test and in accordance with GLP. The result is taken to be reliable.

Description of key information

EC50 (48-h): > 100 mg/l, mobility, Daphnia magna

Additional information

A 48-hour EC₅₀value of > 25 mg/l and NOEC of ≥ 35 mg/l have been determined for the effects of the test substance on mobility of Daphnia magna. The results are expressed relative to nominal concentrations of the test substance.The corresponding mean measured concentration of the substance in the treated test medium over the course of the test could not be determinate. No effects could be detected up to the highest tested concentration but the maximum concentration used (25 mg/l) was well below the predicted solubility of the substance (13000 mg/l) and so does not provide an accurate representation of the likely toxicity of the substance. Therefore it was considered appropriate to read across from the structurally analogous substance, N-ethyl-3-trimethoxysilyl-2-methylpropanamine (CAS No. 227085-51-0). A limit test was conducted at a test concentration of 100 mg/l (OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test, RCC Ltd, 2001).

No effects were observed at this concentration to Daphnia magna. As the substance is subject to rapid hydrolysis, it is therefore likely that the test organisms were also exposed to hydrolysis products retained in the test media.