Registration Dossier
Registration Dossier
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EC number: 915-790-0 | CAS number: -
Endpoint summary
Administrative data
Description of key information
The substance was considered corrosive to skin (in a conservative approach) and severely irritating to eyes
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irreversible damage)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
The substance was tested as a formulation (69% active) in a reliable in vivo skin irritation study and a reliable in vivo eye irritation study. In the skin irritation study the test material gave rise to persistant erythema and dry skin which were still seen at the end of the study (day 15). In addition skin necrosis was reported. The necrosis observed corresponds to a lesion of the superficial layers of the skin (epidermis) occurring 72 hours for one animal or at day 5 for another. These lesions heal quickly but with the presence of a crust for one animal until day 10. It is not an eschar (complete necrosis of the skin, including the dermis). In the eye irritation study the test material gave rise to severe eye irritation, including neovascularisation which persisted until the end of the observation period (day 22).
Justification for selection of skin irritation / corrosion
endpoint:
Only one study available. Study compliant with GLP and testing
guidelines.
Justification for selection of eye irritation endpoint:
Only one study available. Study compliant with GLP and testing
guidelines.
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: highly irritating
Justification for classification or non-classification
Given the severe skin responses seen with the formulation, the substance is conservatively classified as Corrosive, category 1C. Given the severe eye response seen with the same formulation, the substance is also classified for Eye Damage, category 1, with hazard statement H314 cause severe skin burns and eye damage
STOT-SE Cat.3 for respiratory irritation is not required. Exposure via the inhalation route will be unlikely to occur. Consequently, despite the irritant/corrosive nature of the substance, respiratory irritation is not expected.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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