Registration Dossier
Registration Dossier
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EC number: 203-818-8 | CAS number: 110-95-2
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented study which meets basic scientific principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- BASF-Test: 5 rats per group per sex were intraperitoneally administered different doses of the test substance. Animals were observed for clinical signs for 14 days and necropsy was performed on surviving animals as well as on animals that died during the observation period.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- N,N,N',N'-tetramethyltrimethylenediamine
- EC Number:
- 203-818-8
- EC Name:
- N,N,N',N'-tetramethyltrimethylenediamine
- Cas Number:
- 110-95-2
- Molecular formula:
- C7H18N2
- IUPAC Name:
- N,N,N',N'-tetramethyltrimethylenediamine
- Details on test material:
- - Name of test material (as cited in study report): Tetramethylpropandiamin-1,3
- Analytical purity: 99 %
- Physical state: liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Dr. Thomae GmbH, Biberach, Germany
- Age at study initiation: ca. 12 weeks
- Mean weight at study initiation: 197 g (males); 183 g (females)
- Fasting period before study: 16 h
- Housing: 5 per cage; V-II-A cages, type DK-III (Fa. Becker & Co, Castrop Rauxel)
- Diet: Ssniff R
- Water: ad libitum
- Acclimation period: at least 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 - 26 °C
- Humidity (%): 45 - 75
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
- Doses:
- 50, 100 and 215 mg/kg bw (0.5, 1.0 and 2.15% respectively)
- No. of animals per sex per dose:
- 5
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 83.2 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: based on interpolation
- Mortality:
- 50 mg/kg bw: 0/10 animals died
100 mg/kg bw: 6/10 animals died
215 mg/kg bw: 10/10 animals died
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
