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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Not many details available

Data source

Reference
Reference Type:
publication
Title:
The toxicity and metabolism of ethylenediaminetetraacetic, diethylenetriaminepentaacetic, and meso-2,3-diaminobutanetetraacetic acids
Author:
Pleskova A, Hladka A, Trnovec T
Year:
1967
Bibliographic source:
Bratislavske Lekarske Listy 47, 540-547

Materials and methods

Test guideline
Qualifier:
no guideline required
Principles of method if other than guideline:
acute study via iv and ip injection
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
not specified
Details on test material:
no data

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
other: intravenous and intraperitoneal
Vehicle:
not specified
Doses:
no exact data
No. of animals per sex per dose:
no data
Control animals:
not specified

Results and discussion

Effect levelsopen allclose all
Sex:
not specified
Dose descriptor:
LD50
Effect level:
5 544 mg/kg bw
Based on:
test mat.
Remarks on result:
other: intravenous injection
Sex:
not specified
Dose descriptor:
LD50
Effect level:
8 893 mg/kg bw
Based on:
test mat.
Remarks on result:
other: intraperitoneal injection

Applicant's summary and conclusion

Conclusions:
Intravenous administration of EDTA-CaNa2 in rabbits resulted in an LD 50 value of 5544 mg/kg bw, and intraperitoneal administration in an LD50 value of 8893 mg/kg bw.
Executive summary:

On mice the toxicity of sodium and calcium salts of the meso-2,3 -diaminebutanetetraacetic (CaNa2 -DBTA), diethylenetriaminepentaacetic (CaNa3 -DTPA), and ethylenediaminetetraacetic (CaNa2 -EDTA) acids was determined. LD50 of CaNa2 -EDTA following i. v. injection is 5.54 g/kg bw, after i. p. injection, 8.89 g/kg bw, that of CaNa3 -DTPA after i. v. injection is 0.75 g/kg bw and of CaNa2 -DBTA after i. p. injection, 4.64 g/kg bw.