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Particle size distribution (Granulometry)

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Reference
Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
22 December 2009-03 February 2010
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Study has been performed according to ISO, CIPAC and OECD guidelines and according to GLP principles.
Qualifier:
according to
Guideline:
other: BS ISO 13320-1:1999
Deviations:
no
Qualifier:
according to
Guideline:
other: CIPAC MT 187
Deviations:
no
Qualifier:
according to
Guideline:
OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
Laser scattering/diffraction
Remarks:
The analysis was carried out using the Dry Powder Module. The sample was analysed using the Malvern Mastersizer 2000 laser Diffraction Analyser
Type of distribution:
other: laser diffraction particle size analysis
Percentile:
D50
Mean:
23.292 µm
Remarks on result:
other: Migrated from fields under 'Mass median diameter' as D50 percentile. No source field for Standard deviation.
Percentile:
D10
Mean:
< 7.206 µm
St. dev.:
0.158
Percentile:
D50
Mean:
< 11.933 µm
St. dev.:
0.078
Percentile:
D90
Mean:
< 19.206 µm
St. dev.:
0.26

32.84% by volume of sample was seen to be < 10.00 µm.

Conclusions:
Using the laser diffraction test (with the Dry Powder Module), the Mass Median Aerodynamic Diameter (MMAD) of the test substancewas determined to be 23.292 µm.

Description of key information

Using the laser diffraction test (with the Dry Powder Module), the Mass Median Aerodynamic Diameter (MMAD) of the test substancewas determined to be 23.292 µm.

Additional information