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Key value for chemical safety assessment

Effects on fertility

Effect on fertility: via oral route
Dose descriptor:
NOAEL
400 mg/kg bw/day
Additional information

From the test results follows that no significant adverse effects for reproduction for parents and the development of pups were found. Only for the reproduction of females certain changes in treatment of the highest (1000 mg/kg/day) dose level (decreased number of corpora lutea, implantations with effect on litter data) were observad. This changes were not found in the middle (400 mg/kg/day) and in the lowest (160 mg/kg/day) doses for females. This effect findings were not dependent on the dose.

No significant effects (in all doses) for fertility of parent males and for pups development were found.

 

The NOAEL (No Observed Adverse Effect Level) for the REPRODUCTION of males was established at 1000 mg/kg body weight/day.

The NOAEL (No Observed Adverse Effect Level) for the REPRODUCTION of females was established at 400 mg/kg body weight/day.

The NOAEL (No Observed Adverse Effect Level) for the DEVELOPMENT of pups was established at 1000 mg/kg body weight/day.


Short description of key information:
The test substance - Reaction product of Distillates (petroleum), acid-treated heavy naphtenic and calcium oxide - was tested for reproduction toxicity using the OECD Test Guideline No. 421 Reproduction/Developmental Toxicity Screening Test, Adopted by the Council on July 27th 1995.

Justification for classification or non-classification