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EC number: 232-140-5 | CAS number: 7789-00-6
The significantly lower liver weights seen in females treated with sodium dichromate are not considered to be of toxicological significance as they are associated with low concurrent control values.
Sodium chromate, sodium dichromate and potassium dichromate (moistened with saline) were administered for 24 hours under occluive conditions to the shorn dorsal skin of groups of New Zealand White Rabbits (5/sex). Animals were observed for 14 days.
Deaths occurred in the groups treated with sodium chromate (1F), sodium dichromate (1M, 3F) and potassium dichromate (2F). Signs of systemic toxcity and local dermal effects were observed in each treatment group. Bodywieghts were unaffected by treatment. Gross necropsy did not reveal any clearly treatment-related effects. Significantly higher absolute and relative liver weights seen in sodium dichromate-treated animals are associated with low concurrnet controls and are considered to be of minimal toxicological significance.
The acute dermal LD50 values for each of the compounds investigated was therefore found to be >2000 mg/kg bw.
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