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Administrative data

Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
30 January - 21 February 2020
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2020
Report date:
2020

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Version / remarks:
2006
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Version / remarks:
EC No. 440/2008
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7950 (Vapor Pressure)
Version / remarks:
1996
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
effusion method: vapour pressure balance

Test material

Constituent 1
Chemical structure
Reference substance name:
(R*,R*)-1,4-dimercaptobutane-2,3-diol
EC Number:
222-468-7
EC Name:
(R*,R*)-1,4-dimercaptobutane-2,3-diol
Cas Number:
3483-12-3
Molecular formula:
C4H10O2S2
IUPAC Name:
1,4-disulfanylbutane-2,3-diol
Specific details on test material used for the study:
Batch No.: 44606300 / 50774
Storage Conditions: 2°C to 8°C, under nitrogen

Results and discussion

Vapour pressureopen allclose all
Key result
Temp.:
20 °C
Vapour pressure:
0.019 Pa
Remarks on result:
other: extrapolated vapour pressure
Key result
Temp.:
25 °C
Vapour pressure:
0.031 Pa
Remarks on result:
other: extrapolated vapour pressure
Key result
Temp.:
50 °C
Vapour pressure:
0.29 Pa
Remarks on result:
other: extrapolated vapour pressure

Any other information on results incl. tables

The vapour pressure was measured in the temperature range from 27 to 58°C. The measured vapour pressure values together with the measured temperatures are given in the table in the next section "overall remarks".

From the measured data points of the vapour pressure curve the constants A and B of the Antoine equation: log10(p) = A + B/T = A + B/(C+t) can be derived by regression of the data points to A = 11.0169; B = -3734.45; C = 273.15.

Applicant's summary and conclusion

Conclusions:
The vapour pressure of the test item 1,4-Dithiothreitol (CAS no. 3483-12-3) was calculated for the temperatures 20, 25 and 50°C by interpolation and extrapolation of the measured vapour pressure curve, according to Regulation EC No. 440/2008 Method A.4. Vapour Pressure and OECD Test Guideline 104 (2006).
The vapour pressure of the test item was 1.9 × 10-2 Pa at 20°C, 3.1 × 10-2 Pa at 25°C and 2.9 × 10-1 Pa at 50°C.
Executive summary:

The vapour pressure of the test item1,4-Dithiothreitol(CAS no. 3483-12-3)was calculated for the temperatures 20, 25 and 50 °C by interpolation and extrapolation of the measured vapour pressure curve, according to Regulation EC No. 440/2008 Method A.4.Vapour PressureandOECD Test Guideline 104 (2006).

 Temperature / °C  Vapour pressure / Pa
 20  1.9 × 10-2
 25  3.1 × 10-2
 50  2.9 × 10-1

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