Registration Dossier
Registration Dossier
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EC number: 222-468-7 | CAS number: 3483-12-3
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Administrative data
- Endpoint:
- relative self-ignition temperature (solids)
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance is a solid having a melting point <= 160°C
- Justification for type of information:
- See further information in the cross-ref.
Cross-reference
- Reason / purpose for cross-reference:
- data waiving: supporting information
Reference
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 30 January - 21 February 2020
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.1 (Melting / Freezing Temperature)
- Version / remarks:
- EC No. 440/2008
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 102 (Melting point / Melting Range)
- Version / remarks:
- 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7200 (Melting Point / Melting Range)
- Version / remarks:
- 1998
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- differential scanning calorimetry
- Specific details on test material used for the study:
- Batch No.: 44606300 / 50774
Storage Conditions: 2°C to 8°C, under nitrogen - Key result
- Melting / freezing pt.:
- 42.44 °C
- Atm. press.:
- >= 1 000.7 - <= 1 001.7 hPa
- Decomposition:
- no
- Conclusions:
- The test item 1,4-Dithiothreitol (CAS no. 3483-12-3) has a melting point of 42.4°C at atmospheric pressure (1001 – 1002 hPa) as determined by differential scanning calorimetry according to Regulation EC No 440/2008 Method A.1. and OECD Test Guideline 102 (1995).
- Executive summary:
The test item 1,4-Dithiothreitol (CAS no. 3483-12-3) has a melting point of 42.4°C at atmospheric pressure (1001 – 1002 hPa) as determined by differential scanning calorimetry according to Regulation EC No 440/2008 Method A.1. and OECD Test Guideline 102 (1995).
During the heating phase a distinct endothermic effect was observed in the temperature range of 40 – 60°C, which can be assigned to the melting of the test item. As the onset temperatures in both tests deviate by less than 0.5 K from their mean value of 42.44°C, this temperature can be used as melting point. The test item has a melting point of 42.4 °C.
Results of the DSC-measurement
| No. | Sample weight/mg | Onset of Effect/°C | Range of Effect/°C | Weight loss/mg | Atmosperhic Presure/HPa |
| PN19051 | 8.91 | 42.28 271.83 |
40 – 60 (endo) 250 – 320 (endo) |
8.91 | 1000.7 |
| PN19053 | 8.35 | 42.60 269.71 |
40 – 60 (endo) 250 – 320 (endo) |
8.34 | 1001.7 |
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
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