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Administrative data

Endpoint:
relative self-ignition temperature (solids)
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
the study does not need to be conducted because the substance is a solid having a melting point <= 160°C
Justification for type of information:
See further information in the cross-ref.
Cross-reference
Reason / purpose for cross-reference:
data waiving: supporting information
Reference
Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
30 January - 21 February 2020
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Version / remarks:
EC No. 440/2008
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Version / remarks:
1995
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7200 (Melting Point / Melting Range)
Version / remarks:
1998
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
differential scanning calorimetry
Specific details on test material used for the study:
Batch No.: 44606300 / 50774
Storage Conditions: 2°C to 8°C, under nitrogen
Key result
Melting / freezing pt.:
42.44 °C
Atm. press.:
>= 1 000.7 - <= 1 001.7 hPa
Decomposition:
no

During the heating phase a distinct endothermic effect was observed in the temperature range of 40 – 60°C, which can be assigned to the melting of the test item. As the onset temperatures in both tests deviate by less than 0.5 K from their mean value of 42.44°C, this temperature can be used as melting point. The test item has a melting point of 42.4 °C.

Results of the DSC-measurement

No.   Sample weight/mg Onset of Effect/°C   Range of Effect/°C Weight loss/mg   Atmosperhic Presure/HPa
 PN19051  8.91  42.28
271.83
 40 – 60 (endo)
250 – 320 (endo)
 8.91  1000.7
 PN19053  8.35  42.60
269.71
 40 – 60 (endo)
250 – 320 (endo)
 8.34 1001.7
Conclusions:
The test item 1,4-Dithiothreitol (CAS no. 3483-12-3) has a melting point of 42.4°C at atmospheric pressure (1001 – 1002 hPa) as determined by differential scanning calorimetry according to Regulation EC No 440/2008 Method A.1. and OECD Test Guideline 102 (1995).
Executive summary:

The test item 1,4-Dithiothreitol (CAS no. 3483-12-3) has a melting point of 42.4°C at atmospheric pressure (1001 – 1002 hPa) as determined by differential scanning calorimetry according to Regulation EC No 440/2008 Method A.1. and OECD Test Guideline 102 (1995).

Data source

Materials and methods

Results and discussion

Applicant's summary and conclusion