Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
relative density
Type of information:
experimental study
Adequacy of study:
key study
Study period:
28 January 2020
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2020
Report date:
2020

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 109 (Density of Liquids and Solids)
Version / remarks:
2012
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.3 (Relative Density)
Version / remarks:
Regulation EC No. 440/2008
Deviations:
no
Qualifier:
according to guideline
Guideline:
other: EPA OCSPP Test Guideline 830.7300. Density/Relative Density/Bulk Density
Version / remarks:
2002
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
other: gas comparison pycnometer

Test material

Constituent 1
Chemical structure
Reference substance name:
(R*,R*)-1,4-dimercaptobutane-2,3-diol
EC Number:
222-468-7
EC Name:
(R*,R*)-1,4-dimercaptobutane-2,3-diol
Cas Number:
3483-12-3
Molecular formula:
C4H10O2S2
IUPAC Name:
1,4-disulfanylbutane-2,3-diol
Specific details on test material used for the study:
Batch No.: 44606300 / 50774
Storage Conditions: 2°C to 8°C, under nitrogen

Results and discussion

Densityopen allclose all
Key result
Type:
relative density
Density:
1.377 other: dimensionless
Temp.:
20 °C
Remarks on result:
other: The relative density is calculated by dividing the density of the test item by the density of water at 4 °C.
Type:
density
Density:
1.377 g/cm³
Temp.:
20 °C
Remarks on result:
other: the density of the test item is given as the mean value of two measurements.

Any other information on results incl. tables

The individual density measurements were 1.37770 g/cm3 (test 1) and 1.37653 g/cm3 (test 2).

Applicant's summary and conclusion

Conclusions:
According to OECD Test Guidelines 109 (2012), Regulation EC No. 440/2008 Method A.3. and EPA OCSPP Test Guideline 830.7300 (2002), the relative density of the test item 1,4 Dithiothreitol (CAS no. 3483-12-3) at 20°C ± 0.01 °C (compared to water at 4°C) was determined to be 1.377.
Executive summary:

According to OECD Test Guidelines 109 (2012), Regulation EC No. 440/2008 Method A.3. and EPA OCSPP Test Guideline 830.7300 (2002), the relative density of the test item 1,4 Dithiothreitol (CAS no. 3483-12-3) at 20°C ± 0.01 °C (compared to water at 4°C) was determined to be 1.377.