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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
Remarks:
In vivo micronucleus tests in bone marrow erythrocytes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
publication
Title:
Dicarboxylic acid (C4–C6) dimethylester, mixture (dimethyl succinate, dimethyl adipate, dimethyl glutarate and their mixture)
Year:
2007
Bibliographic source:
The MAK-Collection for Occupational Health and Safety

Materials and methods

Type of assay:
mammalian erythrocyte micronucleus test

Test material

Constituent 1
Chemical structure
Reference substance name:
Dimethyl succinate
EC Number:
203-419-9
EC Name:
Dimethyl succinate
Cas Number:
106-65-0
Molecular formula:
C6H10O4
IUPAC Name:
dimethyl succinate

Test animals

Species:
rat
Strain:
Fischer 344
Sex:
male

Administration / exposure

Route of administration:
intraperitoneal
Duration of treatment / exposure:
3 days
Doses / concentrationsopen allclose all
Dose / conc.:
312.5 mg/kg bw/day
Dose / conc.:
625 mg/kg bw/day
Dose / conc.:
1 250 mg/kg bw/day
No. of animals per sex per dose:
5 males per dose

Results and discussion

Test results
Sex:
male
Genotoxicity:
negative
Additional information on results:
no information on PCE/NCE

Applicant's summary and conclusion

Conclusions:
Under the test conditions, the substance was not genotoxic.