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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Overall, the substance has an acute oral LD50 of about 5000 mg/kg bw.

The substance has a inhalation RD50 of 1600 mg/m3.

The substance has an acute dermal LD50 of > 5000 mg/kg bw.

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Referenceopen allclose all

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Species:
rat
Sex:
male/female
Route of administration:
oral: unspecified
Vehicle:
not specified
No. of animals per sex per dose:
5 animals per sex
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 500 - < 5 000 mg/kg bw

500 mg/kg body weight: + 0/10; kidney changes (dilated renal pelvis, discoloration, tan nodules).

5000 mg/kg body weight: + 10/10; lethargy; rales (only 1 ♀); died animals: lungs: discoloration and oedema

Interpretation of results:
study cannot be used for classification
Conclusions:
The substance has a LD50 which falls between 500 and 5000 mg/kg bw.
Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Species:
rat
Sex:
male/female
Route of administration:
oral: unspecified
Vehicle:
not specified
Doses:
5000 mg/kg bw
No. of animals per sex per dose:
5 animals per sex
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw

5000 mg/kg body weight: + 0/10; lethargy; 2 animals with rales, 2 animals with discoloration of the lungs and dilated renal pelvis.

Interpretation of results:
study cannot be used for classification
Conclusions:
The substance has a oral LD50 > 5000 mg/kg.

Acute toxicity: via inhalation route

Link to relevant study records
Reference
Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Species:
mouse
Sex:
not specified
Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
not specified
Sex:
not specified
Dose descriptor:
other: RD50
Remarks:
exposure concentration producing a 50% respiratory rate decrease
Effect level:
1 600 mg/m³ air
Interpretation of results:
study cannot be used for classification
Conclusions:
The substance has a RD50 of 1600 mg/m3 in mouse.

Acute toxicity: via dermal route

Link to relevant study records
Reference
Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Species:
rabbit
Sex:
male/female
Type of coverage:
not specified
Vehicle:
not specified
No. of animals per sex per dose:
5 animals per sex
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw

5000 mg/kg body weight: + 0/10; 2 animals in 1. or 2nd week: body weight ↓

Interpretation of results:
GHS criteria not met
Conclusions:
The substance has a dermal LD50 > 5000 mg/kg bw.

Additional information

Justification for classification or non-classification

According to CLP Regulation, the substance has not to be classified for acute oral/inhalation/dermal toxicity.