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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
20 February 2020 to 12 March 2020
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Version / remarks:
27 July 1995
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Version / remarks:
4 March 2016
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7840 (Water Solubility)
Version / remarks:
March 1998
Deviations:
no
GLP compliance:
yes
Type of method:
flask method
Specific details on test material used for the study:
- Purity/Composition correction factor: No correction factor required
Key result
Water solubility:
0.045 g/L
Conc. based on:
test mat.
Incubation duration:
>= 24 - <= 72 h
Temp.:
20 °C
pH:
>= 3.6 - <= 4.4
Details on results:
PRELIMINARY TEST
The content of test material dissolved in the water sample was 0.0511 g/L.

MAIN STUDY
The results for the samples taken at 24, 48 and 72 hours are provided in the Table below.
The maximum difference of the concentrations determined in the 24, 48 and 72 hour test samples was ≤ 15 %. Based on this, the water solubility of the test material is given as the mean value of the analysed concentrations.
Small responses at the retention time of the test material were detected in the chromatograms of the pre-treated sample from the blank water mixture. It was considered to derive from carry-over in the analytical system since similar responses were found in the analytical blanks. The maximum contribution to the samples was 0.018 %. It was considered that it has no significant effect on the results of the test samples.

Water Solubility of the Test Material

Stirring time

(hours)

Analysed concentration

(g/L)

Mean

(g/L)

Maximum

difference (%)

pH

24

0.0449

0.0449

0.29

4.4

48

0.0449

3.8

72

0.0450

3.6
Conclusions:
Under the conditions of the study, the water solubility of the test material was determined to be 0.0449 g/L at 20 °C. The pH of the aqueous samples was between 3.6 and 4.4.
Executive summary:

The water solubility of the test material was investigated in a study which was conducted in accordance with the standardised guidelines OECD 105, EU Method A.6 and EPA OPPTS 830.7840, under GLP conditions, following the Flask Method.

Under the conditions of the study, the water solubility of the test material was determined to be 0.0449 g/L at 20 °C. The pH of the aqueous samples was between 3.6 and 4.4.

Description of key information

Under the conditions of the study, the water solubility of the test material was determined to be 0.0449 g/L at 20 °C. The pH of the aqueous samples was between 3.6 and 4.4.

Key value for chemical safety assessment

Water solubility:
0.045 g/L
at the temperature of:
20 °C

Additional information

The water solubility of the test material was investigated in a study which was conducted in accordance with the standardised guidelines OECD 105, EU Method A.6 and EPA OPPTS 830.7840, under GLP conditions, following the Flask Method. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).

Under the conditions of the study, the water solubility of the test material was determined to be 0.0449 g/L at 20 °C. The pH of the aqueous samples was between 3.6 and 4.4.