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Physical & Chemical properties

Water solubility

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water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
18th March 2019 to 7th June 2019
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
according to guideline
OECD Guideline 105 (Water Solubility)
According to the test design, a phase separation via centrifugation was not necessary. This deviation was considered to have no impact on quality and integrity of the study
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method
Specific details on test material used for the study:
Test material is a UVCB
Key result
Water solubility:
398 µg/L
Conc. based on:
test mat.
Incubation duration:
72 h
20 °C

Water Solubility Results at 20 °C

1) Incubation Time = Time after application

2) Calculated concentration = Exact weight of the external standard taken into account

 Incubation Time [h]

Calculated Concentration [µg/L]

Replicate 1

Calculated Concentration [µg/L]

Replicate 1

 408.65  443  366  
 410.73  408  360  
 428.93  407  374  
 430.93  424  374  
 433.57  415  403   Overall
 Mean  419  376  398
 Deviation [%]  8.9  11.9  11.7
The water solubility of the test item was determined to be 398 μg/L (20°C, pH 6)
Executive summary:

Water solubility for the test substance was determined in accordance with OECD guideline 105. The solubility for the test item, in purified water (18.2 MQ/cm), was determined employing the flask method with slow stirring approach at 20+/-0.5deg with incubation at test temperature for 72h before the first sampling. The analytical method (LC-MS/MS, external standard) was validated and tested with satisfactory results in regards to linearity, accuracy , precision and specificity.


The water solubility of the test item was determined to be 398 μg/L (20°C, pH 6)

Description of key information

Key value for chemical safety assessment

Water solubility:
398 µg/L
at the temperature of:
20 °C

Additional information