Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 701-350-3 | CAS number: -
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 18th March 2019 to 7th June 2019
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- yes
- Remarks:
- According to the test design, a phase separation via centrifugation was not necessary. This deviation was considered to have no impact on quality and integrity of the study
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Specific details on test material used for the study:
- Test material is a UVCB
- Key result
- Water solubility:
- 398 µg/L
- Conc. based on:
- test mat.
- Incubation duration:
- 72 h
- Temp.:
- 20 °C
- pH:
- 6
- Conclusions:
- The water solubility of the test item was determined to be 398 μg/L (20°C, pH 6)
- Executive summary:
Water solubility for the test substance was determined in accordance with OECD guideline 105. The solubility for the test item, in purified water (18.2 MQ/cm), was determined employing the flask method with slow stirring approach at 20+/-0.5deg with incubation at test temperature for 72h before the first sampling. The analytical method (LC-MS/MS, external standard) was validated and tested with satisfactory results in regards to linearity, accuracy , precision and specificity.
The water solubility of the test item was determined to be 398 μg/L (20°C, pH 6)
Reference
Water Solubility Results at 20 °C
1) Incubation Time = Time after application
2) Calculated concentration = Exact weight of the external standard taken into account
| Incubation Time [h] | Calculated Concentration [µg/L] Replicate 1 |
Calculated Concentration [µg/L] Replicate 1 |
|
| 408.65 | 443 | 366 | |
| 410.73 | 408 | 360 | |
| 428.93 | 407 | 374 | |
| 430.93 | 424 | 374 | |
| 433.57 | 415 | 403 | Overall |
| Mean | 419 | 376 | 398 |
| Deviation [%] | 8.9 | 11.9 | 11.7 |
Description of key information
Key value for chemical safety assessment
- Water solubility:
- 398 µg/L
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
