Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Endpoint summary
Administrative data
Description of key information
LD50 (rat, oral) > 2000 mg/kg bw
LD50 (rat, dermal) > 2000 mg/kg bw
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
The acute toxicity of the substance is evaluated by considering data on similar substances. Justification for Read Across is given in Section 13 of IUCLID.
Acute oral toxicity
Three studies are available. In the study conducted in 1984 according to the directive 67/548/CEE, 5 male and 5 female rats were exposed to 15600 mg/kg bw of the test material, a control run in parallel. No mortality was observed in the 14 -day observation period and a LD50 > 15600 mg/kg bw was determined. In the other two studies conducted in 2010 according to the OECD 420 one animal was dosed at 300 mg/kg and five animals were dosed at 2000 mg/kg in one of the study, instead five animals were dosed at 2000 mg/kg bw in the second study. LD50 was determined to be greater than 2000 mg/kg bw in both studies.
Acute dermal toxicity
Two studies are available and the acute toxicity via dermal route is evaluated in a Weight of Evidence approach. Both studies were performed according to the OECD Guideline 402. Five male and five female rats were exposed to the substance at 2000 mg/kg bw for 24 hours in a semiocclusive coverage. No mortality was observed and the LD50 was determined as greater than 2000 mg/kg bw.
Justification for classification or non-classification
Based on the available data and the criteria of the CLP Regulation (EC) No. 1272/2008, the substance is not classified as acute toxic. Furthermore, a component of the UVCB substance classified in Acute Tox.4 (H302, H312, H332) is in a percentage that does not allow the classification of the UVCB substance as toxic or harmful via the oral, dermal or inhalation route.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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