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Particle size distribution (Granulometry)

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Reference
Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From August 22nd, 2018 to August 24th, 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions - Method A: Particle Size Distribution (effective hydrodynamic radius)
Deviations:
no
Qualifier:
according to
Guideline:
ISO 13320 (Particle size analysis - Laser diffraction methods)
Deviations:
no
Qualifier:
according to
Guideline:
other: CIPAC MT 187
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
Laser scattering/diffraction
Type of particle tested:
primary particle
Type of distribution:
volumetric distribution
Key result
Percentile:
D10
Mean:
1.4 µm
St. dev.:
0.054
Key result
Percentile:
D50
Mean:
10.17 µm
St. dev.:
0.054
Key result
Percentile:
D90
Mean:
22.67 µm
St. dev.:
0.054
Key result
Percentile:
other: d4,3
Mean:
11.33 µm
St. dev.:
0.054

Table 1. Results of particle size distribution

 

Particles size

1

2

3

4

5

Average

[µm]

d10

1.39

1.39

1.39

1.42

1.39

1.40

d50

10.16

10.16

10.16

10.21

10.16

10.17

d90

22.62

22.60

22.60

22.91

22.60

22.67

* d4,3, [µm]

11.31

11.31

11.31

11.43

11.31

11.33

*Mass moment mean (De Brouckere Mean Diameter); Standard deviation, [µm]: 0.054; Relative standard deviation, [%]: 0.47

Conclusions:
The average particle size results for the test item are: D10 = 1.4 μm, D50 =10.17 μm, D90 = 22.67 μm, D4,3 = 11.33.
Executive summary:

The particle size distribution for the test substance was determined according to OECD 110 / CIPAC MT 187 / ISO 13320-1 (Laser diffraction method) under GLP conditions. 0.1 g of the tested material were dispersed in 0.5% Tween 80 aqueous solution and transferred drop by drop to the dispersion unit of the measuring equipment until the appropriate concentration was reached. Based on the measurement of the light scattered by the particles, the volumetric particle size distribution was determined. The average particle size results for the test item were: D10 = 1.4 μm, D50 = 10.17 μm, D90 = 22.67 μm, D4,3 = 11.33 μm (Mass moment mean - De Brouckere Mean Diameter).

Description of key information

Key study. Method according to OECD 110/ CIPAC MT 187 / ISO 13320-1 (laser diffraction method), GLP study. The average particle size results for the test item are: D10 = 1.4 μm, D50 = 10.17 μm, D90 = 22.67 μm, D4,3 = 11.33 μm (Mass moment mean - De Brouckere Mean Diameter).

Additional information