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Ecotoxicological information

Long-term toxicity to fish

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Description of key information

The lowest chronic NOEC or EC10 for fish, 76 µg V/L, was observed for the effect of V2O5 in a 30-day growth test with second generation flagfish larvae (Jordanella floridae) originating from exposed fish (Holdway and Sprague, 1979).

Corrected for the molecular weight of

divanadyl pyrophosphate (CAS no. 65232 -89 -5): 230 µg/L

Key value for chemical safety assessment

EC10, LC10 or NOEC for freshwater fish:
230 µg/L

Additional information

Data on the chronic toxicity of divanadyl pyrophosphate (CAS no. 65232 -89 -5) to fish are not available; therefore, a read-across approach to structurally similar is followed based on all information available for inorganic pentavalent V compounds.

All information on the long-term toxicity to fish is based on non-guideline studies. One study was selected as key study and three studies serve as supporting studies. The information from two other sources is disregarded due to major methodological deficiencies (Birge, 1978 and Birge et al., 1980). The effect values reported are all based on the concentration of vanadium.

The most sensitive endpoint was determined in a two-generation fish test with Jordanella floridae as test species (Holdway & Sprague, 1979). Exposure was performed under flow-through conditions. Test concentrations were analytically verified. The test started with the exposure of larvae. The test was run for 96 days until the young fish were able to reproduce. The eggs from these exposed fish were exposed again. Mortality, growth and abnormalities of first and second generation fish were assessed after different periods. Exposure duration was 96-d for the first generation and 30 days for the second generation. The most sensitive endpoint was growth (weight) of the second generation fish: 30-d EC10 = 76 µg/L (meas.).

For the assessment of the toxicity of divanadyl pyrophosphate (CAS no. 65232 -89 -5), the effect value based on the vanadium concentration must be corrected for the molecular weight of divanadyl pyrophosphate (33.1 % V). The corrected 30 -d EC10 is 230 µg/L (= 76 g V/L).

It can be concluded that long-term exposure to vanadium has an effect on fish.

Source

Substance

Effect value

Endpoint

Remark

Holdway & Sprague (1979)

CAS 1314-62-1

30-d EC10 = 76 µg/L (meas.)

Two-generation fish test: growth of second generation

Key study;Jordanella floridae

Perez-Benito et al. (2006)

CAS 13718-26-8

NOEC = 218 µg/L (meas.)

Lifespan of guppies: males

Supporting study;Poecilia reticulata

Kimball (1978)

CAS 1314-62-1

28-d EC10 = 203 µg/L (meas.)

Fish early life stage: weight

Supporting study;Pimephales promelas

Chakraborty et al. (1998)

CAS 7803-55-6

30-d NOEC = 870 µg/L (nom.)

Adult fish: sublethal effects: weight

Supporting study;Clarias batrachus

Birge et al. (1980)

CAS 1314-62-1

28-d EC10 = 33.8 µg/L (meas.)

Embryo-larval bioassay: mortality and teratogenesis

Disregarded:Oncorhynchus mykiss

Birge (1978)

CAS 1314-62-1

7-d LC50 = 1600 µg/L (meas.)

Embryo-larval bioassay: mortality and teratogenesis

Disregarded:Carassius auratus

Birge (1978)

CAS 1314-62-1

28-d LC50 = 160 µg/L (meas.)

Embryo-larval bioassay: mortality and teratogenesis

Disregarded:Oncorhynchus mykiss