Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 407-130-0 | CAS number: 65232-89-5
The lowest chronic NOEC or EC10 for fish, 76 µg V/L, was observed for the effect of V2O5 in a 30-day growth test with second generation flagfish larvae (Jordanella floridae) originating from exposed fish (Holdway and Sprague, 1979).
Corrected for the molecular weight of
divanadyl pyrophosphate (CAS no. 65232 -89 -5): 230 µg/L
Data on the chronic toxicity of divanadyl pyrophosphate (CAS no. 65232 -89 -5) to fish are not available; therefore, a read-across approach to structurally similar is followed based on all information available for inorganic pentavalent V compounds.
All information on the long-term toxicity to fish is based on non-guideline studies. One study was selected as key study and three studies serve as supporting studies. The information from two other sources is disregarded due to major methodological deficiencies (Birge, 1978 and Birge et al., 1980). The effect values reported are all based on the concentration of vanadium.
The most sensitive endpoint was determined in a two-generation fish test with Jordanella floridae as test species (Holdway & Sprague, 1979). Exposure was performed under flow-through conditions. Test concentrations were analytically verified. The test started with the exposure of larvae. The test was run for 96 days until the young fish were able to reproduce. The eggs from these exposed fish were exposed again. Mortality, growth and abnormalities of first and second generation fish were assessed after different periods. Exposure duration was 96-d for the first generation and 30 days for the second generation. The most sensitive endpoint was growth (weight) of the second generation fish: 30-d EC10 = 76 µg/L (meas.).
For the assessment of the toxicity of divanadyl pyrophosphate (CAS no. 65232 -89 -5), the effect value based on the vanadium concentration must be corrected for the molecular weight of divanadyl pyrophosphate (33.1 % V). The corrected 30 -d EC10 is 230 µg/L (= 76 g V/L).
It can be concluded that long-term exposure to vanadium has an effect on fish.
Holdway & Sprague (1979)
30-d EC10 = 76 µg/L (meas.)
Two-generation fish test: growth of second generation
Key study;Jordanella floridae
Perez-Benito et al. (2006)
NOEC = 218 µg/L (meas.)
Lifespan of guppies: males
Supporting study;Poecilia reticulata
28-d EC10 = 203 µg/L (meas.)
Fish early life stage: weight
Supporting study;Pimephales promelas
Chakraborty et al. (1998)
30-d NOEC = 870 µg/L (nom.)
Adult fish: sublethal effects: weight
Supporting study;Clarias batrachus
Birge et al. (1980)
28-d EC10 = 33.8 µg/L (meas.)
Embryo-larval bioassay: mortality and teratogenesis
7-d LC50 = 1600 µg/L (meas.)
28-d LC50 = 160 µg/L (meas.)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Close Do not show this message again