Registration Dossier
Registration Dossier
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EC number: 828-229-9 | CAS number: 7019-19-4
PBT assessment
Administrative data
PBT assessment: overall result
- Name:
- 2-hydroxyoctanal/1-hydroxyoctan-2-one
- Type of composition:
- legal entity composition of the substance
- State / form:
- liquid
- Reference substance:
- 2-hydroxyoctanal/1-hydroxyoctan-2-one
- PBT status:
- the substance is not PBT / vPvB
- Justification:
PERSISTENCE ASSESSMENT
The biodegradation of 1 -hydroxyoctan-2 -one in an OECD 301F study was 76.8% within 28 days and the substance is considered readily biodegradable meeting the 10d window (see IUCLID Section 5.2.1). Therefore the criteria for 'P' for the PBT / vPvB Assessment is not fulfilled.
BIOACCUMULATION ASSESSMENT
The registered substance 1-hydroxyoctan-2-one was found to have an experimental log Kow value of 1.683 at 20°C and pH ~8.3 (see IUCLID Section 4.7) and therefore a low potential for bioaccumulation and biomagnification is expected. The 'B' criteria for the PBT /vPvB Assessment is not fulfilled.
TOXICITY ASSESSMENT
The acute 48h EC50 value for invertebrates (daphnia magna) exposed to 1-hydroxyoctan-2-one was determined to be 39.1 mg/L (nominal). The 72h EC50 value for algae exposed to 1-hydroxyoctan-2-one was determined to be 105.1 mg/L and 45.53 mg/L based on growth rate and yield, respectively. 72h EC10 values were 39.3 and 17.6 mg/L for effects on growth rate and yield, respectively. The 72h NOEC based on growth rate was determined to be 12.5 mg/l. The registration substance is neither mutagenic, reprotoxic, carcinogenic, germ cell mutagenic nor toxic for reproduction. The registration substance is not classified for chronic health effects. Therefore the 'T' criteria for the PBT / vPvB Assessment is not fulfilled.
- Likely routes of exposure:
Humans: Dermal and Eye
Environment: trace amounts are expected to be released via wastewater effluent discharge(s) from municipal STPs to surface waters
Reference
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