Molybdenum, N,N-bis(C11-14-branched and linear alkyl)carbamodithioate oxo thioxo complexes

Endpoint summary

Description of key information

Acute Toxicity: Oral

Key study:

The single-dose oral toxicity of the test substance was evaluated in Sprague-Dawley rats in a study performed to the standardised guideline OECD 401 under GLP conditions. A limit test was performed in which one group of five male and five female rats received a single oral administration of the test article at a dose level of 2000 mg/kg body weight. Following dosing, the limit test rats were observed daily and weighed weekly. A gross necropsy examination was performed on all limit test animals at the time of scheduled euthanasia (day 14).

 

No mortality occurred during the limit test. Clinical abnormalities noted during the study were observed in one female and consisted on incidences of decreased activity, soft stools, urine/faecal staining and rales. Body weight gain was normal for all animals during the test period. No gross internal findings were observed at necropsy on study day 14.

 

Under the conditions of this test, the acute oral LD50 was estimated to be greater than 2000 mg/kg in the rat (Springborn Laboratories, Inc., 1996.

 

Acute Toxicity: Dermal and Inhalation

The acute dermal and inhalation toxicity studies have been waived.

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Reference

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

11 January 1996 to 15 April 1996

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Version / remarks:

Limit test

Deviations:

no

GLP compliance:

yes

Test type:

acute toxic class method

Limit test:

yes

Specific details on test material used for the study:

- Description: Dark brown very viscous liquid
- Storage: Room temperature

Species:

rat

Strain:

Sprague-Dawley

Remarks:

Crl: CD(R)BR VAF/Plus(R)

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Charles River Laboratories, Inc., Portage, Michigan
- Females (if applicable) nulliparous and non-pregnant: Yes
- Age at study initiation: Young adult
- Weight at study initiation: approximately 200 - 300 g
- Fasting period before study: Overnight
- Housing: The animals were housed individually in suspended stainless steel cages
- Diet (e.g. ad libitum): PMI Certified Rodent Chow #5002 (purina Mills, Inc.) was provided ad libitum to the animals throughout the study (except during fasting)
- Water (e.g. ad libitum): Municipal tap water following treatment by reverse osmosis was available ad mibitum throughout the study
- Acclimation period: Minimum of 5 days

ENVIRONMENTAL CONDITIONS
- Temperature (°C): ~22
- Humidity (%): ~55
- Air changes (per hr): 10-15
- Photoperiod (hrs dark / hrs light): 12/12

Route of administration:

oral: gavage

Vehicle:

corn oil

Details on oral exposure:

The test material was mixed with corn oil to produce a 50% w/v concentration for dose administration.

Doses:

2000 mg/kg

No. of animals per sex per dose:

5

Control animals:

no

Preliminary study:

No mortality occurred during the limit test

Key result

Sex:

male/female

Dose descriptor:

LD50

Remarks:

no deaths reported at this dose level

Effect level:

> 2 000 mg/kg bw

Based on:

test mat.

Mortality:

No mortality

Clinical signs:

other: One female had incidenses of decreased activity, soft stools, urine/fecal staining, and rales.

Gross pathology:

No gross findings

Interpretation of results:

GHS criteria not met

Conclusions:

Under the conditions of the study, the acute oral LD50 was estimated to be greater than 2000 mg/kg in the rat.

Executive summary:

The single-dose oral toxicity of the test material was evaluated in Sprague-Dawley rats in a study performed to the standardised guideline OECD 401 under GLP conditions. A limit test was performed in which one group of five male and five female rats received a single oral administration of the test material at a dose level of 2000 mg/kg body weight. Following dosing, the limit test rats were observed daily and weighed weekly. A gross necropsy examination was performed on all limit test animals at !he time of scheduled euthanasia (day 14).

 

No mortality occurred during the limit test. Clinical abnormalities noted during the study were observed in one female and consisted of incidences of decreased activity, soft stools, urine/faecal  staining and rales. Body weight gain was normal for all animals during the test period. No gross internal findings were observed at necropsy on study day 14.

 

Under the conditions of this test, the acute oral LD50 of the test material was estimated to be greater than 2000 mg/kg in the rat.

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed

Dose descriptor:

LD50

Value:

2 000 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion

Endpoint conclusion:

no study available

Acute toxicity: via dermal route

Endpoint conclusion

Endpoint conclusion:

no study available

Justification for classification or non-classification

The acute oral LD50 was estimated to be greater than 2000 mg/kg in the rat.