Registration Dossier
Registration Dossier
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EC number: 948-019-1 | CAS number: -
Endpoint summary
Administrative data
Link to relevant study record(s)
- Endpoint:
- basic toxicokinetics, other
- Type of information:
- other: Assessment based upon available information.
- Adequacy of study:
- key study
- Study period:
- May 2018
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Information selected for the toxicokinetic assessment is primarily study data. Studies were conducted inaccordance with recognised testing guideline.
- Conclusions:
- In conclusion, based upon the available data, bioavailability ofthe substance, reaction mass of molybdenum, bis(C11-14branched and linear alkyl)carbamodithioato-.kappa.S,.kappa.S')oxodioxo-thioxodi-, molybdenum, bis(C11-14branched and linear alkyl)carbamodithioato-.kappa.S,.kappa.S')dioxodi-thioxodi-, molybdenum, bis(C11-14branched and linear alkyl)carbamodithioato-.kappa.S,.kappa.S')oxodi-thioxothioxodi-, and bis(C11-14branched and linear alkyl) dithiocarbamic acid,is expected to be very limited and the substance has very low systemic toxicity.
Reference
The physical state of the substance, reaction mass of molybdenum, bis(C11-14branched and linear alkyl)carbamodithioato-.kappa.S,.kappa.S')oxodioxo-thioxodi-, molybdenum, bis(C11-14branched and linear alkyl)carbamodithioato-.kappa.S,.kappa.S')dioxodi-thioxodi-, molybdenum, bis(C11-14branched and linear alkyl)carbamodithioato-.kappa.S,.kappa.S')oxodi-thioxothioxodi-, and bis(C11-14branched and linear alkyl) dithiocarbamic acid,is a brown liquid at room temperature and therefore, potential inhalation of the substance is negligible.
The substance is a substance of Unknown or Variable composition, Complex reaction products or Biological materials (UVCB) with multiple constituents and itswater solubility and partition coefficient (Log Kow)were estimated to be < 1.19x 10-6mg/L and > 20, respectively,using the EPI Suite™ software. The typical molecular mass of the substance (C54H108Mo2N2O3-xS5+xwhere x= 0-2) is 1188 Daltons. These data indicate that the substance is large (> 500 Daltons), extremely low water soluble (< 0.1 mg/L), and very highly lipophilic (Log Pow > 5.6) molecule, and therefore, the substance is not bioavailable via the oral route in accordance with Lipinski's rule of five. In addition, repeated dose oral toxicity studies in rats did not show any systemic effects up to 1000 mg/kg/day, the highest doses tested in both 14-day oral toxicity study and combined repeated dose oral toxicity study with the reproductive/developmental toxicity screening test. No information is currently available on possible degradation products produced in the gastrointestinal tract.
The extremely low water solubility, very high lipophilicity, and large molecular mass of the substance also indicate that it is not expected to be absorbed via the dermal route. The Magnusson and Kligman maximization test in the guinea pigshowed that the substance is not a skin sensitizer.
Additionally, the ready biodegradability test of the substance showed that it was 2% after 28 days and was not considered readily biodegradable. The substance is therefore expected to have low potential for bioaccumulation in aquatic organisms although the substance is persistent and its Log Pow exceeds 5.
In conclusion, based upon the available data, bioavailability ofthe substance, reaction mass of molybdenum, bis(C11-14branched and linear alkyl)carbamodithioato-.kappa.S,.kappa.S')oxodioxo-thioxodi-, molybdenum, bis(C11-14branched and linear alkyl)carbamodithioato-.kappa.S,.kappa.S')dioxodi-thioxodi-, molybdenum, bis(C11-14branched and linear alkyl)carbamodithioato-.kappa.S,.kappa.S')oxodi-thioxothioxodi-, and bis(C11-14branched and linear alkyl) dithiocarbamic acid,is expected to be very limited and the substance has very low systemic toxicity.
Description of key information
In conclusion, based upon the available data, bioavailability ofthe substance, reaction mass of molybdenum, bis(C11-14branched and linear alkyl)carbamodithioato-.kappa.S,.kappa.S')oxodioxo-thioxodi-, molybdenum, bis(C11-14branched and linear alkyl)carbamodithioato-.kappa.S,.kappa.S')dioxodi-thioxodi-, molybdenum, bis(C11-14branched and linear alkyl)carbamodithioato-.kappa.S,.kappa.S')oxodi-thioxothioxodi-, and bis(C11-14branched and linear alkyl) dithiocarbamic acid,is expected to be very limited and the substance has very low systemic toxicity.
Key value for chemical safety assessment
Additional information
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