Dihydrogen bis[P,P-dioctyl diphosphato(2-)-O'',O''''][hydroxyacetato(2-)-O1,O2]titanate(2-), branched and linear

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

12 March - 26 March 1986

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

test procedure in accordance with national standard methods with acceptable restrictions

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1986

Report date:

1986

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: Test: Acute Oral Toxicity Test (OSHA) Occupational Safety & Hazards Act, Part 1910

Deviations:

not specified

GLP compliance:

no

Test type:

other: Acute oral toxicity test (Occupational Safety & Hazards Act, 1910 (OSHA))

Test material

Test material information

1

Reference substance name:

Dihydrogen bis[P,P-dioctyl diphosphato(2-)-O'',O''''][hydroxyacetato(2-)-O1,O2]titanate(2-), branched and linear

EC Number:

271-571-3

EC Name:

Dihydrogen bis[P,P-dioctyl diphosphato(2-)-O'',O''''][hydroxyacetato(2-)-O1,O2]titanate(2-), branched and linear

Cas Number:

68585-64-8

Molecular formula:

not applicable (UVCB substance)

IUPAC Name:

({bis[(2-ethylhexyl)oxy]phosphoryl}oxy)[(2-{[({bis[(2-ethylhexyl)oxy]phosphoryl}oxy)(hydroxy)phosphoryl]oxy}-4-oxo-1,3-dioxa-2-titanacyclopentan-2-yl)oxy]phosphinic acid; {[({bis[(2-ethylhexyl)oxy]phosphanyl}oxy)({[({bis[(2-ethylhexyl)oxy]phosphoryl}oxy)(hydroxy)phosphoryl]oxy})[(2-hydroxyacetyl)oxy]titanio]oxy}({bis[(2-ethylhexyl)oxy]phosphoryl}oxy)phosphinic acid

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Age at study initiation: adult
- Fasting period before study: the rats were fasted before dosing
- Diet: ad libitum
- Water: ad libitum

Administration / exposure

Route of administration:

oral: unspecified

Vehicle:

corn oil

Details on oral exposure:

VEHICLE
- corn oil
- Concentration in vehicle: 10%

MAXIMUM DOSE VOLUME APPLIED: 5 mL/kg bw

Doses:

500 mg/kg bw

No. of animals per sex per dose:

10

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: not specified
- Necropsy of survivors performed: yes
- Other examinations performed: body weight

Results and discussion

Effect levels

Key result

Sex:

female

Dose descriptor:

other: LD10

Effect level:

500 mg/kg bw

Based on:

test mat.

Remarks on result:

other: A single oral application of the test substance to rats at a dose of 500 mg/kg body weight induced death in one female rat. Since only one animal died, no LD50 value could be determined.

Mortality:

One female rat died during the study period at a dose of 500 mg/kg bw.

Gross pathology:

No toxic signs observed at terminal necropsy for the surviving rats. The non-surviving rat displayed hyperemia of the small intestine and fluid in the thoracic cavity.

Any other information on results incl. tables

Table 1: Mortality data

Starting Dose (mg/kg bw)	Sex	Number of Animals	Number of Intercurrent Deaths	Weight change (g) and (% gain or loss)
500	male	5	0/5	+ 122.4 g (57.7%)
500	female	5	1/5	+ 49 g (19.8%)

bw = body weight

Applicant's summary and conclusion

Interpretation of results:

other: CLP/EU classification according to Regulation(EC) No. 1272/2008

Conclusions:

Under the conditions of the present study, a single oral application of the test substance to rats at a dose of 500 mg/kg body weight induced death in one female rat. A LD50 could not be determined.
CLP: Categrory 4, H302