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EC number: 290-272-9 | CAS number: 90106-49-3
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- Data comes from an online compilation using secondary data sources. There is no experimental study reference, however data provided from validated QSAR.
- Qualifier:
- according to guideline
- Guideline:
- other: ECOSAR
- Version / remarks:
- v1.11
- Principles of method if other than guideline:
- QSAR
- GLP compliance:
- not specified
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 0.719 mg/L
- Conclusions:
- LC50 of daphnia is 0.719 mg/L for p-alpha pinene.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- Data comes from an online compilation using secondary data sources. There is no experimental study reference, however data provided from validated QSAR.
- Qualifier:
- according to guideline
- Guideline:
- other: ECSAR
- Version / remarks:
- v1.11
- Principles of method if other than guideline:
- QSAR
- GLP compliance:
- not specified
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 13.38 mg/L
- Conclusions:
- LC50 of daphnia is 13.38 mg/L for borneol.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- Data comes from an online compilation using secondary data sources. There is no experimental study reference, however data provided from validated QSAR.
- Qualifier:
- according to guideline
- Guideline:
- other: ECOSAR
- Version / remarks:
- v1.11
- Principles of method if other than guideline:
- QSAR
- GLP compliance:
- not specified
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 0.615 mg/L
- Conclusions:
- LC50 of daphnia is 0.615 mg/L for camphene.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- Data comes from an online compilation using secondary data sources. There is no experimental study reference, however data provided from validated QSAR.
- Qualifier:
- according to guideline
- Guideline:
- other: ECOSAR
- Version / remarks:
- v1.11
- Principles of method if other than guideline:
- QSAR
- GLP compliance:
- not specified
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 9.019 mg/L
- Conclusions:
- LC50 of daphnia is 9.019 mg/L for camphor.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- Data comes from an online compilation using secondary data sources. There is no experimental study reference, however data provided from validated QSAR.
- Qualifier:
- according to guideline
- Guideline:
- other: ECOSAR
- Version / remarks:
- v1.11
- Principles of method if other than guideline:
- QSAR
- GLP compliance:
- not specified
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 7.669 mg/L
- Conclusions:
- LC50 of daphnia is 7.669 mg/L for cineol.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- Data comes from an online compilation using secondary data sources. There is no experimental study reference, however data provided from validated QSAR.
- Qualifier:
- according to guideline
- Guideline:
- other: ECOSAR
- Version / remarks:
- v1.11
- Principles of method if other than guideline:
- QSAR
- GLP compliance:
- not specified
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 0.238 mg/L
- Conclusions:
- LC50 of daphnia is 0.238 mg/L for limonene.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- Data comes from an online compilation using secondary data sources. There is no experimental study reference, however data provided from validated QSAR.
- Qualifier:
- according to guideline
- Guideline:
- other: ECOSAR
- Version / remarks:
- v1.11
- Principles of method if other than guideline:
- QSAR
- GLP compliance:
- not specified
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 0.29 mg/L
- Conclusions:
- LC50 of daphnia is 0.29 mg/L for linalol.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- Data comes from an online compilation using secondary data sources. There is no experimental study reference, however data provided from validated QSAR.
- Qualifier:
- according to guideline
- Guideline:
- other: ECOSAR
- Version / remarks:
- v1.11
- Principles of method if other than guideline:
- QSAR
- GLP compliance:
- not specified
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 1.706 mg/L
- Conclusions:
- LC50 of daphnia is 1.706 mg/L for linalyl acetate.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- Data comes from an online compilation using secondary data sources. There is no experimental study reference, however data provided from validated QSAR.
- Qualifier:
- according to guideline
- Guideline:
- other: ECOSAR
- Version / remarks:
- v1.11
- Principles of method if other than guideline:
- QSAR
- GLP compliance:
- not specified
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 0.216 mg/L
- Conclusions:
- LC50 of daphnia is 0.216 mg/L for p-myrcene.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- Data comes from an online compilation using secondary data sources. There is no experimental study reference, however data provided from validated QSAR.
- Qualifier:
- according to guideline
- Guideline:
- other: ECOSAR
- Version / remarks:
- v1.11
- GLP compliance:
- not specified
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 0.615 mg/L
- Conclusions:
- LC50 of daphnia is 0.615 mg/L for beta-pinene.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- Data comes from an online compilation using secondary data sources. There is no experimental study reference, however data provided from validated QSAR.
- Qualifier:
- according to guideline
- Guideline:
- other: ECOSAR
- Version / remarks:
- v1.11
- Principles of method if other than guideline:
- QSAR
- GLP compliance:
- not specified
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 0.313 mg/L
- Conclusions:
- LC50 of daphnia is 0.313 mg/L for sabinene.
Referenceopen allclose all
Description of key information
Based on a weight of evidence approach, the acute toxicity of spanish sage oil to aquatic invertebrates (daphnia) can be estimated using adequate toxicity data of major constituents. Eleven constituents were considered representing more than 83.82% of the UVCB substance.These data are summarized in the table below :
| Consitutent Name | CAS Number | LC50 daphnia (mg/L) | Source |
| Camphor (27.68%) | 76-22-2 | 9.019 | ECOSAR |
| Cineol (23.77%) | 470-82-6 | 7.669 | ECOSAR |
| Camphene (7.08%) | 79-92-5 | 0.615 | ECOSAR |
| Alpha-pinene (5.56) | 80-56-8 |
0.719 | ECOSAR |
| Limonene (4.53%) | 5989-27-5 | 0.238 | ECOSAR |
| Beta-pinene (4.41%) | 127-91-3 | 0.615 | ECOSAR |
| Myrcene (2.77%) | 123-35-3 | 0.216 | ECOSAR |
| Linalyl acetate (2.56%) | 115-95-7 | 1.706 | ECOSAR |
| Borneol (2.5%) | 507-70-0 | 13.38 | ECOSAR |
| Linalol (1.59%) | 78-70-6 | 0.29 | ECOSAR |
| Sabinene (1.37%) | 3387-41-5 | 0.313 | ECOSAR |
The toxicity to daphnia were estimated using the following additivity formulas, as recommended in the Regulation (EC) No 1272/2008 (CLP) section 4.1.3.5.2:
∑ Ci / L(E)C50m = ∑ (Ci / L(E)C50i)
Where,Ci = concentration of component i (weight percentage);
L(E)C50i = LC50 or EC50 for component i, in mg/L; L(E)C50m = L(E)C50 of the part of the mixture with test data.
Based on data presented above, the EC50 value 48 hours for UVCB substance is calculated at 1.103 mg/L for daphnia.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 1.103 mg/L
Additional information
The LC50 daphnia (48h) value for sage oil is estimated at 1.103 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
