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EC number: 290-272-9 | CAS number: 90106-49-3
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- Data comes from an online compilation using secondary data sources. There is no experimental study reference, however data provided from validated QSAR.
- Qualifier:
- according to guideline
- Guideline:
- other: ECOSAR
- Version / remarks:
- v1.11
- Principles of method if other than guideline:
- QSAR
- GLP compliance:
- not specified
- Duration:
- 96 h
- Dose descriptor:
- EL50
- Effect conc.:
- 1.273 mg/L
- Conclusions:
- EC50 of green algae is 1.273 mg/L for alpha pinene.
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- Data comes from an online compilation using secondary data sources. There is no experimental study reference, however data provided from validated QSAR.
- Qualifier:
- according to guideline
- Guideline:
- other: ECOSAR
- Version / remarks:
- v1.11
- Principles of method if other than guideline:
- QSAR
- GLP compliance:
- not specified
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- 1.123 mg/L
- Conclusions:
- EC50 of green algae is 1.123 mg/L for beta-pinene.
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- Data comes from an online compilation using secondary data sources. There is no experimental study reference, however data provided from validated QSAR.
- Qualifier:
- according to guideline
- Guideline:
- other: ECOSAR
- Version / remarks:
- v1.11
- Principles of method if other than guideline:
- QSAR
- GLP compliance:
- not specified
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- 13.795 mg/L
- Conclusions:
- EC50 of green algae is 13.795 mg/L for borneol.
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- Data comes from an online compilation using secondary data sources. There is no experimental study reference, however data provided from validated QSAR.
- Qualifier:
- according to guideline
- Guideline:
- other: ECOSAR
- Version / remarks:
- v1.11
- Principles of method if other than guideline:
- QSAR
- GLP compliance:
- not specified
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- 1.123 mg/L
- Conclusions:
- EC50 of green algae is 1.123 mg/L for camphene.
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- Data comes from an online compilation using secondary data sources. There is no experimental study reference, however data provided from validated QSAR.
- Qualifier:
- according to guideline
- Guideline:
- other: ECOSAR
- Version / remarks:
- v1.11
- Principles of method if other than guideline:
- QSAR
- GLP compliance:
- not specified
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- 10.01 mg/L
- Conclusions:
- EC50 of green algae is 10.01 mg/L for camphor.
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- Data comes from an online compilation using secondary data sources. There is no experimental study reference, however data provided from validated QSAR.
- Qualifier:
- according to guideline
- Guideline:
- other: ECOSAR
- Version / remarks:
- v1.11
- Principles of method if other than guideline:
- QSAR
- GLP compliance:
- not specified
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- 8.805 mg/L
- Conclusions:
- EC50 of green algae is 8.805 mg/L for cineol.
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- Data comes from an online compilation using secondary data sources. There is no experimental study reference, however data provided from validated QSAR.
- Qualifier:
- according to guideline
- Guideline:
- other: ECOSAR
- Version / remarks:
- v1.11
- Principles of method if other than guideline:
- QSAR
- GLP compliance:
- not specified
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- 0.522 mg/L
- Conclusions:
- EC50 of green algae is 0.522 mg/L for limonene.
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- Data comes from an online compilation using secondary data sources. There is no experimental study reference, however data provided from validated QSAR.
- Qualifier:
- according to guideline
- Guideline:
- other: ECOSAR
- Version / remarks:
- v1.11
- Principles of method if other than guideline:
- QSAR
- GLP compliance:
- not specified
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- 3.597 mg/L
- Conclusions:
- EC50 of green algae is 3.597 mg/L for linalol.
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- Data comes from an online compilation using secondary data sources. There is no experimental study reference, however data provided from validated QSAR.
- Qualifier:
- according to guideline
- Guideline:
- other: ECOSAR
- Version / remarks:
- v1.11
- Principles of method if other than guideline:
- QSAR
- GLP compliance:
- not specified
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- 0.497 mg/L
- Conclusions:
- EC50 of green algae is 0.497 mg/L for linalyl acetate.
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- Data comes from an online compilation using secondary data sources. There is no experimental study reference, however data provided from validated QSAR.
- Qualifier:
- according to guideline
- Guideline:
- other: ECOSAR
- Version / remarks:
- v1.11
- Principles of method if other than guideline:
- QSAR
- GLP compliance:
- not specified
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- 0.483 mg/L
- Conclusions:
- EC50 of green algae is 0.483 mg/L for myrcene.
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- Data comes from an online compilation using secondary data sources. There is no experimental study reference, however data provided from validated QSAR.
- Qualifier:
- according to guideline
- Guideline:
- other: ECOSAR
- Version / remarks:
- v1.11
- Principles of method if other than guideline:
- QSAR
- GLP compliance:
- not specified
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- 0.651 mg/L
- Conclusions:
- EC50 of green algae is 0651 mg/L for sabinene.
Referenceopen allclose all
Description of key information
Based on a weight of evidence approach, the acute toxicity of spanish sage oil to aquatic green algae can be estimated using adequate toxicity data of major constituents. Eleven constituents were considered representing more than 83.82% of the UVCB substance.These data are summarized in the table below :
| Consituent Name | CAS Number | EC50 Green algae (mg/L) | Source |
| Camphor (27.68%) | 76-22-2 | 10.100 | ECOSAR |
| Cineol (23.77%) | 470-82-6 | 8.805 | ECOSAR |
| Camphene (7.08%) | 79-92-5 | 1.123 | ECOSAR |
| Alpha-pinene (5.56%) | 80-56-8 | 1.273 | ECOSAR |
| Limonene (4.53%) | 5989-27-5 | 0.522 | ECOSAR |
| Beta-pinene (4.41%) | 127-91-3 | 1.123 | ECOSAR |
| Myrcene (2.77%) | 123-35-3 | 0.483 | ECOSAR |
| Linalyl acetate (2.56%) | 115-95-7 | 0.497 | ECOSAR |
| Borneol (2.5%) | 507-70-0 | 13.795 | ECOSAR |
| Linalol (1.59%) | 78-70-6 | 3.597 | ECOSAR |
| Sabinene (1.37%) | 3387-41-5 | 0.651 | ECOSAR |
The toxicity to green algae were estimated using the following additivity formulas, as recommended in the Regulation (EC) No 1272/2008 (CLP) section 4.1.3.5.2:
∑ Ci / L(E)C50m = ∑ (Ci / L(E)C50i)
Where,Ci = concentration of component i (weight percentage);
L(E)C50i = LC50 or EC50 for component i, in mg/L; L(E)C50m = L(E)C50 of the part of the mixture with test data.
Based on data presented above, the EC50 value 96 hours for UVCB substance is calculated at 1.979 mg/L for green Algae .
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 1.979 mg/L
Additional information
With a EC50 green algae (96h) value of 1.979 mg/l.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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