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Physical & Chemical properties

Boiling point

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Reference
Endpoint:
boiling point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
12 Aug - 21 Sep 2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Remarks:
Study was conducted in accordance with international guidelines and in accordance with GLP. All guideline criteria were met.
Qualifier:
according to
Guideline:
OECD Guideline 103 (Boiling Point)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.2 (Boiling Temperature)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
differential scanning calorimetry
Specific details on test material used for the study:
RADIOLABELLING INFORMATION (if applicable)
- Radiochemical purity: N/A
- Specific activity: N/A
- Locations of the label: N/A
- Expiration date of radiochemical substance: N/A

STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: Room temperature in the dark under nitrogen
- Stability under test conditions: Assumed stable
- Solubility and stability of the test substance in the solvent/vehicle: N/A
- Reactivity of the test substance with the solvent/vehicle of the cell culture medium: N/A

TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing: N/A
- Preliminary purification step (if any): N/A
- Final dilution of a dissolved solid, stock liquid or gel: N/A
- Final preparation of a solid: N/A

FORM AS APPLIED IN THE TEST (if different from that of starting material)

OTHER SPECIFICS: N/A
Key result
Boiling pt.:
>= 217.3 - <= 218.3 °C
Atm. press.:
101.8 kPa

Table 1: Results of DSC Measurements

Thermal Event

Interpretation

Determination

Temperature

˚C

K

Sharp endothermic

Boiling

1

214.14

487.29

2

214.59

487.74

3

217.86

491.01

4

217.75

490.90

As a result of the determinations using pre-pierced crucibles produced sharper endotherms the values obtained from these determinations (determinations 3 and 4) were used to determine the mean boiling point.

Mean boiling point: 217.8 ± 0.5 °C (491.0 ± 0.5 K) at 101.8 kPa (based on determinations 3 & 4)

Conclusions:
The boiling temperature of the substance has been determined to be 217.8 ± 0.5 °C (491.0 ± 0.5 K) at 101.8 kPa (atmospheric pressure).
Executive summary:

The boiling temperature was determined using a technique designed to be compatible with EU Method A.2 and OECD 103 (differntial scanning calorimetry).

During thermal analysis, the onset point of the relevant endothermic peak was stated as the substance boiling point. The boiling point is stated with regard to the ambient pressure during measurement.

The boiling point of the test substance has been determined to be 217.8 ± 0.5 °C (491.0 ± 0.5 K) at 101.8 kPa (atmospheric pressure).

Description of key information

EU Method A.2, 2017 - The boiling temperature was determined using a technique designed to be compatible with EU Method A.2 and OECD 103 (differntial scanning calorimetry).

During thermal analysis, the onset point of the relevant endothermic peak was stated as the substance boiling point. The boiling point is stated with regard to the ambient pressure during measurement.

The boiling point of the test substance has been determined to be 217.8 ± 0.5 °C (491.0 ± 0.5 K) at 101.8 kPa (atmospheric pressure).

Key value for chemical safety assessment

Boiling point at 101 325 Pa:
217.8 °C

Additional information