Registration Dossier

Ecotoxicological information

Endpoint summary

Administrative data

Description of key information

Two key studies are presented for aquatic toxicity, in line with REACH Annex VII data requirements.  Both studies are (Q)SAR predictions using the iSafeRat® HA-QSAR based on a holistic approach for predicting physicochemical and ecotoxicological endpoints (Bicherel and Thomas, 2014).

The 48 hour EL50 to Daphnia sp. of reaction mass of (4R)-4-(2-methoxypropan-2-yl)-1-methylcyclohexene and cis-1-methoxy-4-(2-methoxypropan-2-yl)-1-methylcyclohexane , estimated from the iSafeRat v.2.2 QSAR inputs from each constieunt and, calculations based on thermodynamics of each constituent and there eventual contribution to the toxicity was 30 mg/L.

The 72 hour ErL50 to algae of the reaction mass of (4R)-4-(2-methoxypropan-2-yl)-1-methylcyclohexene and cis-1-methoxy-4-(2-methoxypropan-2-yl)-1-methylcyclohexane , estimated from the iSafeRat v.2.2 QSAR inputs from each constieunt and, calculations based on thermodynamics of each constituent and there eventual contribution to the toxicity was 44 mg/L.

These endpoint values are considered valid for use in risk assessment (including PBT assessment) and classification and labelling. The prediction is adequate as contributing data for the Classification and Labelling or risk assessment of the substance as indicated in REACH Regulation (EC) 1907/2006: Annex XI Section 1.3.

Additional information

For classification and labelling, the principles for both GHS and CLP were applied:

Endpoints used for hazard assessment:

Algae 72h ErL50 (iSafeRat): 44 mg/L

Daphnid 48h EL50 (iSafeRat): 30 mg/L

The following are considered for classification & labelling (GHS Rev5 & CLP (1272/2008)):

Data used for assessment: Acute

48h EC50: 30 mg/L

Substance Rapidly Degradable: No (28d biodegradation = 12 %)

Log Kow: <4

When applying the GHS principles of classification and labelling, the following classifications are applicable to the substance: EH Acute 3, EH Chronic 3.

When applying the CLP principles of classification and labelling, the following classifications are applicable to the substance: Aquatic Chronic 3.