Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Water solubility
Administrative data
Link to relevant study record(s)
Description of key information
Water solubility = in the range of 350548.35 and 369843.51 mg/L at 20.0 ± 0.5 °C, EU Method A6 (visual inspection), Butler & White (2008).
Key value for chemical safety assessment
- Water solubility:
- 350 548.35 mg/L
- at the temperature of:
- 20 °C
Additional information
In the key study Butler & White (2008), the water solubility of the test material was determined under GLP conditions in line with an adaption of the EU Test Method A6. The standard A6 Method was not applicable to this test material due to the high indeterminable saturation levels produced. It was therefore not possible to prepare samples at five times the saturation level as recommended in the guideline. Analysis at the saturation level could not be performed due to the high solubility producing un-filterable mixtures and thus the water solubility was estimated based on visual inspection. This study was assigned a reliability score of 1 in line with the principles for assessing data quality as defined by Klimisch (1997).
Preliminary visual assessments were performed, which, after further investigation and analysis have been reported as the definitive test. All mobile solutions were observed to be colloidal, demonstrated by exhibiting the Tyndall effect. Where possible, analysis was performed by high performance liquid chromatography (HPLC), to establish that the test material was fully dissolved at the dosing rates tested. Samples 1, 2, 3 and 5 were centrifuged, filtered and diluted before analysing by high performance liquid chromatography (HPLC). The results indicated that the test material was fully dissolved at the dosing rates of 1, 10, 20 and 25 % w/w.
Under the conditions of the test, the water solubility of the test material has been determined to be in the range of 26.0 to 27.0 % w/w or in the range of 350548.35 to 369843.51 mg/L at 20.0 ± 0.5 °C and pH 10.5 to 10.6. Therefore the test material is considered to be very soluble.
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