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EC number: 426-650-9 | CAS number: -
The material was applied onto skin and into eyes of rabbits to examine irritating properties of the test item (according OECD guideline 404 and 405, GLP). Application onto skin did not induce any effects or clinical signs. Installation into eyes resulted in transient effects, i.e. opacity in one animals and conjunctival irritation in all animals. All symptoms resolved within 72h. The test material is therefore not considered to be irritating to skin or eyes.
Six healthy New Zealand White rabbits (5 males-1 female) were dosed dermally with the test item for 4h under semi-occlusive conditions (0.5g into intact skin). Dermal reactions were scored at 30 to 60 minutes and 24, 48 and 72 hours after removal of wrappings. Systemic signs were recorded at each observation period. Body weights were recorded pretest. Erythema and edema were absent at all observation intervals. There were no abnormal systemic signs noted during the observation period. In conclusion, the test substance is not considered to be irritating to skin.
33 mg (0.1 ml) of the test material were installed into the conjunctival sac of one eye of one eye each of six healthy New Zealand White rabbits (females). The eyes were examined and scored by the Draize technique at 1, 24, 48 and 72 hours post dose. Sodium fluorescein was used to determine corneal effects following the 24 and 48 hour observation. Body weights were recorded pretest. Corneal opacity and iritis, noted in 1/6 eyes, cleared by 48 hours. Conjunctival irritation, noted in 6/6 eyes, cleared by 72 hours. There were no abnormal systemic signs noted during the observation period. In conclusion, the test substance is not considered to be irritating to skin or eyes.
Classification, Labelling, and Packaging Regulation (EC) No. 1272/2008
The available experimental test data are reliable and suitable for classification purposes under Regulation 1272/2008. As a result the substance is not considered to be classified for irritation under Regulation (EC) No. 1272/2008.
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