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Physical & Chemical properties

Partition coefficient

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
August 2018
Reliability:
1 (reliable without restriction)
Qualifier:
according to guideline
Guideline:
EU Method A.8 (Partition Coefficient - Shake Flask Method)
Version / remarks:
The shake flask method applies only to substantially pure water-soluble substances and 1-octanol, when the log Pow value is in the range of -2 to 4.
In turn, the liquid chromatography (HPLC) method applies when the log Pow value is in the range of 0 to 6.
In case log Pow is out of the ranges mentioned above, an estimation method based on the solubility of the substance in 1-octanol and water is used.
During the initial assessment of the partition coefficient, it was found that for the test substance a log Pow value <-3.5. The value provided is outside the range of applicability of experimental methods for determining the partition coefficient. An estimation method based on the solubility of the substance in 1-octanol and water should have been used to determine the partition coefficient.
Deviations:
yes
Remarks:
see remarks
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method
Partition coefficient type:
octanol-water
Key result
Type:
log Pow
Partition coefficient:
< -3.77
Temp.:
20 °C
pH:
ca. 7
Key result
Type:
Pow
Partition coefficient:
< 0
Temp.:
20 °C
pH:
7
Conclusions:
The estimated logarithm of the decimal 1-octanol / water partition coefficient for vanadyl diascorbate is less than -3.77.
Executive summary:

The estimated logarithm of the decimal 1-octanol / water partition coefficient for vanadyl diascorbate is less than -3.77.

Description of key information

Key value for chemical safety assessment

Log Kow (Log Pow):
-3.77
at the temperature of:
20 °C

Additional information