Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
4 March - 18 April 2008
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: The study has been performed according to OECD and EC guidelines and according to GLP principles.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2008
Report Date:
2008

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
HPLC method
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Aquapel 203
- Substance type: yellow fatty liquid
- Physical state: liquid
- Analytical purity: 89.9%
- Lot/batch No.: G12FY067
- Expiration date of the lot/batch: 12 June 2008
- Stability under storage conditions: stable
- Storage condition of test material: at room temperature in the dark

Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficientopen allclose all
Type:
Pow
Partition coefficient:
> 3 200 000
Temp.:
23 °C
pH:
7
Type:
log Pow
Partition coefficient:
> 6.5
Temp.:
23 °C
pH:
7
Details on results:
The components of the test substance eluted in the gradient of the analytical method with retention times of > 30 minutes. The retention time of 2,4-DDT was 23.4 minutes. Hence, it was concluded that the log Pow of the components of the test substance was > 6.5 (Pow > 3.2 x 10^6).

Applicant's summary and conclusion

Conclusions:
The components of the test substance eluted in the gradient of the analytical method with retention times of > 30 minutes. The retention time of 2,4-DDT was 23.4 minutes. Hence, it was concluded that the log Pow of the components of the test substance was > 6.5 (Pow > 3.2 x 10^6).