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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2000-06-14 to 2002-08-02
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
GLP compliance:
yes (incl. certificate)
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Specific details on test material used for the study:
SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Pine Chemicals Association, Incorporated (1117 Perimeter Center West, Suite 500E, Atlanta, GA 30338, USA);
- Batch no. 7-12-00KMR
- Expiration date of the lot/batch: 2005-07-17
- Purity test date: Not specified

STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: stored under nitrogen in the dark at ambient room temperature
- Stability under test conditions: Not specified

FORM AS APPLIED IN THE TEST (if different from that of starting material) : neutral brown liquid (10% solids)
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
> 1.4 - < 7.9
pH:
ca. 2
Remarks on result:
other: Temperature not reported, assumed to be standard.
Details on results:
The partition coefficient for Resin Acids and Rosin Acids, maleated, potassium salt was estimated to be <-3.0 based on the preliminary solubility of the test item in octanol and water.

In unbuffered media, a partition coefficient of 4.7 was determined. The peak present in the trace is thought to be associated with undissociated components present in the test item. In media adjusted to pH 2, a partition coefficient range of 1.4 to >6 (7.9) was
determined.
Conclusions:
The partition coefficient (Log Pow) range of resin acids and rosin acids, maleated, potassium salts was determined to be 1.4 to >6 (7.9) in media adjusted to pH 2.
Executive summary:

The partition coefficient of resin acids and rosin acids, maleated, potassium salts was determined using HPLC and according to OECD 117 technical guidelines. The partition coefficient (Log Pow) range of resin acids and rosin acids, maleated, potassium salts was determined to be 1.4 to >6 (7.9) in media adjusted to pH 2. In unbuffered media, a partition coefficient of 4.7 was determined.

 

This is a GLP-compliant, guideline study and is considered to be suitable for use as the key study for this endpoint.

Description of key information

The partition coefficients for members of the category Rosin adducts and rosin adduct salts range from 1.5 to >6.5

The partition coefficient of Resin acids and rosin acids, maleated, potassium salts is 1.4 to >6 (7.9).

Key value for chemical safety assessment

Additional information

A GLP-compliant study, conducted according to OECD Guideline 117 (HPLC method), was provided for Resin acids and Rosin acids, maleated, potassium salt (PCA, 2002).

The wide range of partition coefficient values for substances in this category is due to the chemical structures of the substances, as they are composed of ionisable organic acids. The substances in this category are UVCB mixtures and therefore can exhibit more than one peak and log Kow value.