Registration Dossier
Registration Dossier
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EC number: 701-237-9 | CAS number: -
Carcinogenicity
Administrative data
Description of key information
In a well conducted and reported, pre-GLP, dietary Combined Chronic Toxicity / Carcinogenicity study (Huntingdon Research Centre, 1979), conducted using a protocol similar to OECD 453, there was no evidence of neoplastic activity for Complexing Agent - Henkel (sodium salt of 1-hydroxythane-1,1-diphosphonic acid (disodium etidronate)) tested up to 384 and 493 mg/kg bw/day for males and females, respectively.
Key value for chemical safety assessment
Carcinogenicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Carcinogenicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Based on the available carcinogenicity study sodium salt of HEDP does not require classification for carcinogenicity according to Regulation (EC) No 1272/2008.
Additional information
This is the only reliable study available for HEDP or sodium/potassium salts of HEDP.
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