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Diss Factsheets
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EC number: 701-237-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- short-term repeated dose toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- No data
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- abstract
- Remarks:
- not all information could be retrieved from the study report
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- GLP compliance:
- not specified
- Remarks:
- pre GLP
- Limit test:
- no
Test material
- Reference substance name:
- (1-hydroxyethylidene)bisphosphonic acid, sodium salt
- EC Number:
- 249-559-4
- EC Name:
- (1-hydroxyethylidene)bisphosphonic acid, sodium salt
- Molecular formula:
- C2H8O7P2.xNa
- IUPAC Name:
- (1-hydroxyethylidene)bisphosphonic acid, sodium salt
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- nose only
- Vehicle:
- other: no data
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 14 days
- Frequency of treatment:
- 5 hours/day 6 times in 14 days
Doses / concentrations
- Dose / conc.:
- 94 mg/m³ air
- No. of animals per sex per dose:
- No data
- Control animals:
- yes
- Details on study design:
- Post-exposure period: 4 weeks
Results and discussion
Effect levels
- Dose descriptor:
- LOAEC
- Effect level:
- 94 mg/m³ air
- Sex:
- male
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
All dosed animals showed a moderate to high grade subacute or
chronic laryngitis, immediately after exposure, and after the four
week recovery period. During the recovery period, the
laryngitis appeared milder but the presence of foreign body
giant cells indicated an incomplete elimination of the test
compound. It was not possible to determine the nature of
the residues responsible for the chronic laryngitis. Immediately after treatment
all test animals exhibited moderate
inflammation in certain parts of the larynx, which did not
completely recover during the post-exposure four week observation period.
Applicant's summary and conclusion
- Conclusions:
- In a subacute inhalation study, Wistar rats were exposed, nose-only, to the test substance at a concentration of 94 mg/m3, five hours a day,at six days within 14 days. A NOAEC could not be established as inflammation of the larynx was observed immediately following treatment and at the end of the observation period.
- Executive summary:
In a subacute inhalation study, Wistar rats were exposed, nose-only, to the test substance at a concentration of 94 mg/m3, five hours a day,at six days within 14 days. All dosed animals showed a moderate to high grade subacute or chronic laryngitis, immediately after exposure, and after the four week recovery period. During the recovery period, the laryngitis appeared milder but the presence of foreign body giant cells indicated an incomplete elimination of the test compound. It was not possible to determine the nature of the residues responsible for the chronic laryngitis. Immediately after treatment all test animals exhibited moderate inflammation in certain parts of the larynx, which did not completely recover during the post-exposure four four week observation period.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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